August 26, 2011
A new formula for injectable Branched-Chain Amino Acids (BCAA). BCAAs consist of three amino acids; Leucine, Isoleucine; and valine. These amino acids cannot be manufactured within the human body, yet they are vital for many of our functions. BCAAs are supplemented by athletes who require them to prevent muscle loss during exercise and to increase performance. Just as athletes benefit from BCAAs, many patients with chronic and certain acute disease also benefit from supplementing these amino acids.
Since mammals can not biologically synthesize these branched chain amino acids, ingesting them through supplements affects the body positively not only in muscle protein synthesis, but also in fighting against some diseases such as liver failure and catabolic diseases. Red blood cells are regained, hemoglobin strength is improved and muscle inflammation is reduced. Apart from benefiting the skeletal muscle, the mixture of these amino acids in proteins greatly benefit the results to certain athletes that take the right amount of the branched chain amino acids a day. Initially these amino acids already do not develop in the body, so the more these amino acids are consumed through other sources the greater chance there is of inducing a healthy diet. (Shimomura, Yoshiharu. “Branched-Chain Amino Acids in Exercise.” American society for Nutrition (2006): 1-4. Web. 5 Feb 2011)
BCAAs are commonly found OTC in capsule or powder form. The usual oral dosage for muscle preservation and growth is 10g-50g daily. The dosage for the injectable formula is recommended at 1ml-3ml IM following exercise or every day for chronic illness.
Side effects: They are completely safe, no side effects. (Mero A, Leucine Supplementation and intensive training. Sports Med. 1999:27:(6):347-358 )
Here’s the breakdown
What Does Lipotropic Mean?
Lipotropic compounds are substances that help stimulate the breakdown of lipid (fat) during metabolism and, in this way, reduce the accumulation of excess fat in the liver and other tissues. Injections of carefully calibrated doses of natural lipotropic nutrients can optimize your ability to shed fat.
Lipotropic Injections Improve Weight Loss
Many substances have lipotropic properties. The most effective lipotropic agents for weight loss purposes are choline, inositol and methionine. Through their involvement in lipid (fat) metabolism, lipotropic agents help maintain a healthy liver. The liver plays a major role in human metabolism including aiding in the digestion, storage, and distribution of nutrients and the detoxification of metabolic poisons and waste products.
The liver produces and stores glycogen from excess carbohydrates, and later releases it when blood sugar levels fall too low. The liver synthesizes plasma proteins that carry oxygen and nutrients to the body tissues and plasma proteins that carry waste products back to the liver for detoxification. The liver also produces bile, a compound that emulsifies fat so that it can be broken down by digestive enzymes. A lipotropic nutrient is one that promotes or encourages the export of fat from the liver. Lipotropics are necessary for the maintenance of a healthy liver as well as burning the exported fat for additional energy. Without lipotropics such as choline and inositol, fats and bile can become trapped in the liver, causing severe problems such as cirrhosis and blocking fat metabolism. Choline is essential for fat metabolism. Choline functions as a methyl donor and it is required for proper liver function. Like inositol, choline is a lipotropic. Inositol exerts lipotropic effects as well. An “unofficial” member of the B vitamins, inositol has even been shown to relieve depression and panic attacks. Methionine, an essential amino acid, is the major lipotropic compound in humans. When estrogen levels are high, the body requires more methionine. Estrogens reduce bile flow through the liver and increase bile cholesterol levels. Methionine helps deactivate estrogens.
This vitamin is important to keep the brain and nervous system functioning normally and for the formation of red blood cells. By synthesizing and regulating DNA, B12 is involved in cellular metabolism. It also plays a vital role in fatty acid synthesis and energy production. Many medications, certain medical conditions, and the normal aging process can lead to a B12 deficiency.
Choline and Inositol
These chemicals are co-enzymes that are required for the proper metabolism of fats and have the ability to remove fat from the liver. Since brain and nerve cells have a protective covering made of fatty acids, choline and inositol are necessary for normal nerve and brain function.
Choline is a key agent in bile production, and bile emulsifies fats in foods you eat so they can be digested. Without choline, fats can become trapped in the liver, where they can block normal metabolic functions. Choline also helps to emulsify cholesterol so that it mixes with the blood and does not settle on the walls of the arteries.
Choline works in combination with inositol to metabolize fats and cholesterol. The body can produce choline, with the help of vitamin B12, folic acid (vitamin B9) and the amino acid known as methionine. However, the rate your body produces choline may not be adequate to meet daily metabolic needs, particularly during weight loss when a lot of body fat must be broken down. Studies show that diets deficient in choline often result in undesirable changes to liver, kidney and brain functions. For this reason, we often recommend choline injections to our weight loss patients.
Inositol is a member of the B-Complex vitamin group and is a lipotropic agent. It metabolizes fats and cholesterol and helps transport fats in the blood system. Thus, inositol can aid in the redistribution of body fat and can help to lower cholesterol levels by moving cholesterol to the liver where it can be excreted. A lack of inositol has been shown to result in an accumulation of triglycerides (a fat compound made of 3 fatty acids) in the liver.
This chemical is an essential amino acid that participates in fat and protein metabolism. It has lipotropic properties similar to those produced by choline. Methionine is an essential amino acid because your body cannot produce it. It must be supplied by your diet. Your body uses methionine to make proteins and many other important substances. For example, your body requires an adequate supply of methionine to synthesize two other important amino acids cysteine and taurine. Methionine is also one of the nutrients required for the body to produce choline. Therefore, a deficiency of this amino acid will adversely affect fat metabolism by limiting choline production. Methionine levels also affect the amount of sulfur-containing compounds, such as glutathione, in the liver. Glutathione and other sulfur-containing peptides (small proteins) play a critical role in defending against toxic compounds. When higher levels of toxic compounds are present, more methionine is needed.
August 15, 2011
Estrogen and Depression
The sex difference in rates of psychiatric illness beginning at puberty and continuing throughout the reproductive years suggest that the brain’s hormonal environment is the thing which modulate the risk and severity of psychiatric morbidity. Hormones play an integral role in the development and prognosis of psychiatric disorders has been increasing attention, especially along with depression treatment. The male-female contrasts in estrogen production throughout the reproductive years are responsible for the modulating the expression of depression between the sexes. Change in mood reported during the late luteal phase of the menstrual cycle and following childbirth mainly.
There are so many causes of increase in the rate of depression at the time of menopause and the recent research for it does not found any evidence that explain that the major depression increases after menopause, at a time when estrogen levels decline. But the thing is observed that post-menopausal women are increasingly vulnerable to depression as the estrogen production reduces in them. Actually the action of estrogen on neurotransmitter and receptor functioning are having the antidepressant symptoms. The main aim of estrogen is to enhance serotonergic functions like increases synthesis and uptake, post-synaptic receptor responsivity, and leads to up-regulation of 5-HT1 and down-regulation of 5-HT2 serotonin receptors.
Estrogen also increases norepinephrine activity in the brain which are responsible for improving the mood and cognition reported in women on estrogen replacement therapy (ERT) and it also involves changes in monoamine oxidase activity. In non-depressed peri- and post-menopausal women though estrogen has been known to improve mood and sense of well being, estrogen alone but it does not improve mood in women with clinical depression. Estrogen as an adjunct to antidepressant therapy is also helpful.
Recently it is researched that the older depressed women in the age 60 years or more older on ERT who received sertraline had substantially improved well than women receiving sertraline alone. Estrogen augmentation for perimenopausal depression be reserved for a subgroup of women, those suffering from depression like postpartum depression or mood changes related to the menstrual cycle associated with changes in estrogen levels. There is a link between Estrogens and the onset, course and severity of depression suggesting estrogen supplementation may be a useful adjuvant therapy in selected depressed women.
Estrogen Source of Stress
As the survey on depression itself suggest that the stress-related depressions are seen twice in women as compared to men. Estrogens level is the main reason for this happening. Even mild levels of stress which don’t affect men, can affect female very easily as their estrogen levels were elevated as estrogen makes the brain more vulnerable to stress. High levels of estrogen increases brain’s response to stress which is responsible that women are more vulnerable to mental illnesses such as depression and post-traumatic stress disorder (PTSD) than men.
It is known that estrogen can interact with molecular processes involved in the stress response and that certain genetic variations have been demonstrated in clinically depressed women. But how these factors combine to produce the disparity in the prevalence of this disorder is unknown
August 8, 2011
Omega-3 fatty acids are considered essential fatty acids: They are necessary for human health but the body can’ t make them — you have to get them through food. Omega-3 fatty acids can be found in fish, such as salmon, tuna, and halibut, other seafood including algae and krill, some plants, and nut oils. Also known as polyunsaturated fatty acids (PUFAs), omega-3 fatty acids play a crucial role in brain function as well as normal growth and development. They have also become popular because they may reduce the risk of heart disease. The American Heart Association recommends eating fish (particularly fatty fish such as mackerel, lake trout, herring, sardines, albacore tuna, and salmon) at least 2 times a week.
Research shows that omega-3 fatty acids reduce inflammation and may help lower risk of chronic diseases such as heart disease, cancer, and arthritis. Omega-3 fatty acids are highly concentrated in the brain and appear to be important for cognitive (brain memory and performance) and behavioral function. In fact, infants who do not get enough omega-3 fatty acids from their mothers during pregnancy are at risk for developing vision and nerve problems. Symptoms of omega-3 fatty acid deficiency include fatigue, poor memory, dry skin, heart problems, mood swings or depression, and poor circulation.
It is important to have a balance of omega-3 and omega-6 (another essential fatty acid) in the diet. Omega-3 fatty acids help reduce inflammation, and most omega-6 fatty acids tend to promote inflammation. The typical American diet tends to contain 14 – 25 times more omega-6 fatty acids than omega-3 fatty acids.
The Mediterranean diet, on the other hand, has a healthier balance between omega-3 and omega-6 fatty acids. Many studies have shown that people who follow this diet are less likely to develop heart disease. The Mediterranean diet does not include much meat (which is high in omega-6 fatty acids) and emphasizes foods rich in omega-3 fatty acids, including whole grains, fresh fruits and vegetables, fish, olive oil, garlic, as well as moderate wine consumption.
Clinical evidence is strongest for heart disease and problems that contribute to heart disease, but omega-3 fatty acids may also be used for:
People who follow a Mediterranean-style diet tend to have higher HDL or “good” cholesterol levels, which help promote heart health. Inuit Eskimos, who get high amounts of omega-3 fatty acids from eating fatty fish, also tend to have increased HDL cholesterol and decreased triglycerides (fats in the blood). Several studies have shown that fish oil supplements reduce triglyceride levels. Finally, walnuts (which are rich in alpha linolenic acid or LNA, a type of omega-3 fatty acid) have been reported to lower total cholesterol and triglycerides in people with high cholesterol levels.
High blood pressure
Several clinical studies suggest that diets or fish oil supplements rich in omega-3 fatty acids lower blood pressure in people with hypertension. An analysis of 17 clinical studies using fish oil supplements found that taking 3 or more grams of fish oil daily may reduce blood pressure in people with untreated hypertension.
One of the best ways to help prevent heart disease is to eat a diet low in saturated fat and to eat foods that are rich in monounsaturated and polyunsaturated fats (including omega-3 fatty acids). Clinical evidence suggests that EPA and DHA (eicosapentaenoic acid and docosahexaenoic acid, the two omega-3 fatty acids found in fish oil) help reduce risk factors for heart disease, including high cholesterol and high blood pressure. Fish oil has been shown to lower levels of triglycerides (fats in the blood), and to lower risk of death, heart attack, stroke, and abnormal heart rhythms in people who have already had a heart attack. Fish oil also appears to help prevent and treat atherosclerosis (hardening of the arteries) by slowing the development of plaque and blood clots, which can clog arteries.
Large population studies suggest that getting omega-3 fatty acids in the diet, primarily from fish, helps protect against stroke caused by plaque buildup and blood clots in the arteries that lead to the brain. Eating at least 2 servings of fish per week can reduce the risk of stroke by as much as 50%. However, high doses of fish oil and omega-3 fatty acids may increase the risk of bleeding. People who eat more than 3 grams of omega-3 fatty acids per day (equivalent to 3 servings of fish per day) may have higher risk for hemorrhagic stroke, a potentially fatal type of stroke in which an artery in the brain leaks or ruptures.
People with diabetes often have high triglyceride and low HDL levels. Omega-3 fatty acids from fish oil can help lower triglycerides and apoproteins (markers of diabetes), and raise HDL, so eating foods or taking fish oil supplements may help people with diabetes. Another type of omega-3 fatty acid, ALA (from flaxseed, for example) may not have the same benefit as fish oil. Some people with diabetes can’ t efficiently convert LNA to a form of omega-3 fatty acids that the body can use. Also, some people with type 2 diabetes may have slight increases in fasting blood sugar when taking fish oil, so talk to your doctor to see if fish oil is right for you.
Most clinical studies examining omega-3 fatty acid supplements for arthritis have focused on rheumatoid arthritis (RA), an autoimmune disease that causes inflammation in the joints. A number of small studies have found that fish oil helps reduce symptoms of RA, including joint pain and morning stiffness. One study suggests that people with RA who take fish oil may be able to lower their dose of non-steroidal anti-inflammatory drugs (NSAIDs). However, unlike prescription medications, fish oil does not appear to slow progression of RA, only to treat the symptoms. Joint damage still occurs.
Laboratory studies suggest that diets rich in omega-3 fatty acids (and low in the inflammatory omega-6 fatty acids) may help people with osteoarthritis, although more study is needed. New Zealand green lipped mussel (Perna canaliculus), another potential source of omega-3 fatty acids, has been reported to reduce joint stiffness and pain, increase grip strength, and improve walking pace in a small group of people with osteoarthritis. For some people, symptoms got worse before they improved.
An analysis of 17 randomized, controlled clinical trials looked at the pain relieving effects of omega-3 fatty acid supplements in people with RA or joint pain caused by inflammatory bowel disease (IBS) and painful menstruation (dysmenorrhea). The results suggest that omega-3 fatty acids, along with conventional therapies such as NSAIDs, may help relieve joint pain associated with these conditions.
Systemic lupus erythematosus (SLE)
Several small studies suggest that EPA and fish oil may help reduce symptoms of lupus, an autoimmune condition characterized by fatigue and joint pain. However, two small studies found fish oil had no effect on lupus nephritis (kidney disease caused by lupus, a frequent complication of the disease).
Some studies suggest that omega-3 fatty acids may help increase levels of calcium in the body and improve bone strength, although not all results were positive. Some studies also suggest that people who don’ t get enough of some essential fatty acids (particularly EPA and gamma-linolenic acid [GLA], an omega-6 fatty acid) are more likely to have bone loss than those with normal levels of these fatty acids. In a study of women over 65 with osteoporosis, those who took EPA and GLA supplements had less bone loss over 3 years than those who took placebo. Many of these women also experienced an increase in bone density.
Studies have found mixed results as to whether taking omega-3 fatty acids can help depression symptoms. Several studies have found that people who took omega-3 fatty acids in addition to prescription antidepressants had a greater improvement in symptoms than those who took antidepressants alone. However, other studies have found no benefit.
Studies are also mixed on whether omega-3 fatty acids alone have any effect on depression. Depression is a serious illness and you should not try to treat it on your own. See a doctor for help.
In a clinical study of 30 people with bipolar disorder, those who took fish oil in addition to standard prescription treatments for bipolar disorder for 4 months experienced fewer mood swings and relapse than those who received placebo. But another 4-month long clinical study treating people with bipolar depression and rapid cycling bipolar disorder did not find that EPA helped reduce symptoms.
Preliminary clinical evidence suggests that people with schizophrenia may have an improvement in symptoms when given omega-3 fatty acids. However, a recent well-designed study concluded that EPA supplements are no better than placebo in improving symptoms of this condition.
Attention deficit/hyperactivity disorder (ADHD)
Children with attention deficit/hyperactivity disorder (ADHD) may have low levels of certain essential fatty acids (including EPA and DHA). In a clinical study of nearly 100 boys, those with lower levels of omega-3 fatty acids had more learning and behavioral problems (such as temper tantrums and sleep disturbances) than boys with normal omega-3 fatty acid levels.
However, studies examining whether omega-3 fatty acids help improve symptoms of ADHD have found mixed results. A few studies have found that omega-3 fatty acids helped improve behavioral symptoms, but most were not well designed. One study that looked at DHA in addition to stimulant therapy (standard therapy for ADHD) found no effect. More research is needed, but eating foods that are high in omega-3 fatty acids is a reasonable approach for someone with ADHD.
In one clinical study, 13 people with sun sensitivity known as photo dermatitis showed less sensitivity to UV rays after taking fish oil supplements. However, topical sunscreens are much better at protecting the skin from damaging effects of the sun than omega-3 fatty acids. In another study of 40 people with psoriasis, those who took EPA with their prescription medications did better than those treated with the medications alone. However, a larger study of people with psoriasis found no benefit from fish oil.
Inflammatory bowel disease (IBD)
Results are mixed as to whether omega-3 fatty acids can help reduce symptoms of Crohn’ s disease and ulcerative colitis, the two types of IBD. Some studies suggest that omega-3 fatty acids may help when added to medication, such as sulfasalazine (a standard medication for IBD). Others find no effect. More studies are needed. Fish oil supplements can cause side effects that are similar to symptoms of IBD (such as flatulence, belching, bloating, and diarrhea).
Studies examining omega-3 fatty acids for asthma are mixed. In one small, well-designed clinical study of 29 children with asthma, those who took fish oil supplements rich in EPA and DHA for 10 months reduced their symptoms compared to children who took placebo. However, most studies have shown no effect.
A questionnaire given to more than 3,000 people over the age of 49 found that those who ate more fish were less likely to have macular degeneration (a serious age-related eye condition that can progress to blindness) than those who ate less fish. Similarly, a clinical study comparing 350 people with macular degeneration to 500 without the eye disease found that those with a healthy dietary balance of omega-3 and omega-6 fatty acids and more fish in their diets were less likely to have macular degeneration.
In one study of 42 women, they had less menstrual pain when they took fish oil supplements than when they took placebo.
Eating foods rich in omega-3 fatty acids seems to reduce the risk of colorectal cancer. For example, Eskimos, who tend to have a high-fat diet but eat significant amounts of fish rich in omega-3 fatty acids, have a low rate of colorectal cancer. Animal studies and laboratory studies have found that omega-3 fatty acids prevent worsening of colon cancer. Preliminary studies suggest that taking fish oil daily may help slow the progression of colon cancer in people with early stages of the disease. If you have colorectal cancer, ask your doctor before taking any supplements.
Although not all experts agree, women who eat foods rich in omega-3 fatty acids over many years may be less likely to develop breast cancer. More research is needed to understand the effect that omega-3 fatty acids may have on the prevention of breast cancer.
Population based studies of groups of men suggest that a low-fat diet including omega-3 fatty acids from fish or fish oil help prevent the development of prostate cancer.
Fish, plant, and nut oils are the primary dietary source of omega-3 fatty acids. Eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) are found in cold-water fish such as salmon, mackerel, halibut, sardines, tuna, and herring. ALA is found in flaxseeds, flaxseed oil, canola (rapeseed) oil, soybeans, soybean oil, pumpkin seeds, pumpkin seed oil, purslane, perilla seed oil, walnuts, and walnut oil. Other sources of omega-3 fatty acids include sea life such as krill and algae.
Both EPA and DHA can be taken in the form of fish oil capsules. Flaxseed, flaxseed oil, fish and krill oils should be kept refrigerated. Whole flaxseeds must be ground within 24 hours of use, so the ingredients stay active. Flaxseeds are also available in ground form in a special mylar package so that the components in the flaxseeds stay active.
Be sure to buy omega-3 fatty acid supplements made by established companies who certify that their products are free of heavy metals such as mercury, lead, and cadmium.
How to Take It:
Dosing for fish oil supplements should be based on the amount of EPA and DHA, not on the total amount of fish oil. Supplements vary in the amounts and ratios of EPA and DHA. A common amount of omega-3 fatty acids in fish oil capsules is 0.18 grams (180 mg) of EPA and 0.12 grams (120 mg) of DHA. Five grams of fish oil contains approximately 0.17 – 0.56 grams (170 -560 mg) of EPA and 0.072 – 0.31 grams (72 – 310 mg) of DHA. Different types of fish contain variable amounts of omega-3 fatty acids, and different types of nuts or oil contain variable amounts of LNA. Fish oils contain approximately 9 calories per gram of oil.
Children (18 years and younger)
There is no established dose for children. Omega-3 fatty acids are used in some infant formulas. Fish oil capsules should not be used in children except under the direction of a health care provider. Children should avoid eating fish that may be high in mercury, such as shark, swordfish, king mackerel, and tilefish. (See Precautions section.)
Do not take more than 3 grams daily of omega-3 fatty acids from capsules without the supervision of a health care provider, due to an increased risk of bleeding.
- For healthy adults with no history of heart disease: The American Heart Association recommends eating fish at least 2 times per week.
- For adults with coronary heart disease: The American Heart Association recommends an omega-3 fatty acid supplement (as fish oils), 1 gram daily of EPA and DHA. It may take 2 – 3 weeks for benefits of fish oil supplements to be seen.
- For adults with high cholesterol levels: The American Heart Association recommends an omega-3 fatty acid supplement (as fish oils), 2 – 4 grams daily of EPA and DHA. It may take 2 – 3 weeks for benefits of fish oil supplements to be seen.
Because of the potential for side effects and interactions with medications, dietary supplements should be taken only under the supervision of a knowledgeable health care provider.
Omega-3 fatty acids should be used cautiously by people who bruise easily, have a bleeding disorder, or take blood-thinning medications including warfarin (Coumadin) or clopidogrel (Plavix). High doses of omega-3 fatty acids may increase the risk of bleeding.
Fish oil can cause gas, bloating, belching, and diarrhea. Time-release preparations may reduce these side effects, however.
People with either diabetes or schizophrenia may lack the ability to convert alpha-linolenic acid (LNA) to eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), the forms more readily used in the body. People with these conditions should be sure to get enough EPA and DHA from their diets. Also, people with type 2 diabetes may experience increases in fasting blood sugar levels while taking fish oil supplements. If you have type 2 diabetes, use fish oil supplements only under the supervision of a health care provider.
Although studies suggest that eating fish (which includes the omega-3 fatty acids EPA and DHA) may reduce the risk of macular degeneration, a recent study including 2 large groups of men and women found that diets rich in LNA may increase the risk of this disease. Until more information becomes available, people with macular degeneration should get omega-3 fatty acids from sources of EPA and DHA, rather than LNA.
Fish and fish oil may protect against prostate cancer, but LNA may be associated with increased risk of prostate cancer in men. More research in this area is needed.
Some fish may contain potentially harmful contaminants, such as heavy metals (including mercury), dioxins, and polychlorinated biphenyls (PCBs). For sport-caught fish, the U.S. Environmental Protection Agency (EPA) recommends that pregnant or nursing women eat no more than a single 6-ounce meal per week, and young children less than 2 ounces per week. For farm-raised, imported, or marine fish, the U.S. Food and Drug Administration recommends that pregnant or nursing women and young children avoid eating types with higher levels of mercury (such as mackerel, shark, swordfish, or tilefish), and eat up to 12 ounces per week of other fish types.
Buy fish oil from a reputable source that tests to make sure there is no mercury or pesticide residues in its products.
If you are currently being treated with any of the following medications, you should not use omega-3 fatty acid supplements, including eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), and alpha-linolenic acid (LNA), without first talking to your health care provider.
Blood-thinning medications — Omega-3 fatty acids may increase the effects of blood thinning medications, including aspirin, warfarin (Coumadin), and clopedigrel (Plavix). Taking aspirin and omega-3 fatty acids may be helpful in some circumstances (such as in heart disease), but they should only be taken together under the supervision of a health care provider.
Diabetes medications — Taking omega-3 fatty acid supplements may increase fasting blood sugar levels. Use with caution if taking medications to lower blood sugar, such as glipizide (Glucotrol and Glucotrol XL), glyburide (Micronase or Diabeta), glucophage (Metformin), or insulin. Your doctor may need to increase your medication dose. These drugs include:
- Glipizide (Glucotrol and Glucotrol XL)
- Glyburide (Micronase or Diabeta)
- Metformin (Glucophage)
Cyclosporine — Cyclosporine is a medication given to people with organ transplants. Taking omega-3 fatty acids during cyclosporine (Sandimmune) therapy may reduce toxic side effects, such as high blood pressure and kidney damage, associated with this medication.
Etretinate and topical steroids — Adding omega-3 fatty acids (specifically EPA) to the drug therapy etretinate (Tegison) and topical corticosteroids may improve symptoms of psoriasis.
Cholesterol-lowering medications — Following dietary guidelines, including increasing the amount of omega-3 fatty acids in your diet and reducing the omega-6 to omega-3 ratio, may help a group of cholesterol lowering medications known as statins to work more effectively. These medications include:
- Atorvastatin (Liptor)
- Lovastatin (Mevacor)
- Simvastatin (Zocor)
Nonsteroidal anti-inflammatory drugs (NSAIDs) — In an animal study, treatment with omega-3 fatty acids reduced the risk of ulcers from nonsteroidal anti-inflammatory drugs (NSAIDs). NSAIDs include ibuprofen (Motrin or Advil) and naproxen (Aleve or Naprosyn). More research is needed to see whether omega-3 fatty acids would have the same effects in people.
August 5, 2011
What causes testosterone deficiency?
Testosterone is a hormone produced by the testicles and is responsible for the proper development of male sexual characteristics, and is important for maintaining muscle bulk, adequate levels of red blood cells, bone density, sense of well-being, and sexual and reproductive function.
Inadequate testosterone production is not a common cause of erectile dysfunction (ED). When ED does occur with decreased testosterone production, testosterone replacement therapy may improve the ED.
As a man ages, the amount of testosterone in his body gradually declines. This natural decline starts after age 30 and continues throughout life. The significance of this decline is controversial and poorly understood.
Symptoms of testosterone deficiency:
- decreased sex drive
- decreased sense of well-being
- depressed mood
- difficulties with concentration and memory
- erectile dysfunction
What are the changes that occur in the body with testosterone deficiency?
Changes that occur with testosterone deficiency include:
- a decrease in muscle mass, with an increase in body fat
- variable effects on cholesterol metabolism
- a decrease in hemoglobin and possibly mild anemia
- fragile bones (osteoporosis)
- a decrease in body hair
How do I find out if I have a testosterone deficiency?
The only accurate way to detect the condition is to have your doctor measure the amount of testosterone in your blood. It sometimes may take several measurements of testosterone to be sure if a patient has a deficiency, since levels of testosterone tend to fluctuate throughout the day. The highest levels of testosterone are generally in the morning. This is why doctors prefer, if possible, to obtain early morning levels of testosterone.
What options are available for testosterone replacement?
The options available for testosterone replacement are:
- intramuscular injections, generally every two or three weeks
- testosterone patches worn either on the body or on the scrotum (the sac that contains the testicles). These patches are used daily. The body patch application is rotated between the buttocks, arms, back or abdomen.
- testosterone gels that are applied daily to the shoulders, upper arms, or abdomen.
For a free consultation on what would work best for you, contact us at:
firstname.lastname@example.org or call us at 866-641-CORE (2673)
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Vitamin D benefits are experienced to the fullest extent by people who maintain optimum vitamin D body stores and blood levels.
They can expect better health across the board – longer life (reduction in death from all causes), fewer diseases, stronger bones and muscles, fewer infections, less depression, pain and inflammation. In short, more enjoyment of life.
New vitamin D benefits are still being discovered, almost everywhere researchers look. Here are some of the more important ones discovered so far:
Vitamin D regulates calcium and phosphorus
The first intimation of vitamin D’s vital role was in 1782, when it was discovered that cod liver oil cures rickets (a disease of growing children whose bones bend due to lack of strength). Of course, they didn’t know then that it was vitamin D in the oil that did the job.
Vitamin D itself was isolated in the 1920’s, but for several decades, all that was known about its usefulness was that it prevented rickets.
In fact, vitamin D plays a major role in the absorption of calcium and phosphorus, and in their proper utilization. This helps keep our bones and teeth strong, and stops calcium depositing where it shouldn’t (for example in our blood vessels, heart and kidneys).
Vitamin D is essential to a healthy immune system
Vitamin D helps the immune system to fight infections. With a near-optimum blood level of vitamin D, you can expect fewer colds, ‘flu, and other unwelcome opportunists (including Swineflu).
Not only does Vitamin D enhance your immunity, but it inhibits the development of destructive auto-immune diseases such as diabetes, rheumatoid arthritis, lupus and multiple sclerosis.
Vitamin D is a major inhibitor of cancer, and part of this effect may be attributed to the increased vigilance of the immune system.
Vitamin D promotes cellular differentiation
Vitamin D encourages cell differentiation (differentiated cells are needed to perform specialized functions effectively) and also slows down the rate at which cells multiply, or proliferate.
Both of these effects contribute to vitamin D’s cancer-fighting ability. Cancer cells are characterized by a lack of differentiation and by rapid proliferation.
Vitamin D is a potent anti-inflammatory
Chronic inflammation is coming into prominent focus as a cause of many disease processes, including major killers such as heart disease and cancer.
Vitamin D is a powerful anti-inflammatory agent, which may also contribute to its effectiveness in reducing some types of muscular pain.
Vitamin D helps regulate blood sugar levels
Optimum levels of vitamin D protect against diabetes (both type 1 and type 2), insulin resistance and hyperglycemia. Diabetes is usually associated with very low levels of vitamin D.
The pancreas also needs sufficient vitamin D in order to make and secrete insulin.
Getting enough vitamin D helps blood sugar control. It may also help prevent serious diabetic complications.
Vitamin D helps lower blood pressure
Maintaining adequate levels of vitamin D helps reduce the risk of hypertension. And optimum levels actually tend to reduce blood pressure in hypertensive people.
Vitamin D protects against low-level nuclear radiation
Dr Daniel Hayes PhD describes many ways in which vitamin D may protect the body from the effects of low-level radiation, such as may occur after a nuclear accident. His paper was published in the International Journal of Low Radiation (Sept 2008)
It makes sense that a nutrient that requires you to expose yourself to strong sunlight would help protect against electromagnetic radiation, doesn’t it?.
With the disaster at Fukushima looming large in everyone’s mind, this is a very useful vitamin D benefit.
Vitamin D benefits, or helps prevent, diseases
Scientists are continually reporting that low blood levels of vitamin D are associated with one disease after another. (High vitamin D levels may be protective.)
These diseases have all been linked to low vitamin D levels:
Bones weak (easy to fracture)
Cancer (all types)
Colds and ‘flu
Chronic obstructive pulmonary disease
Dental cavities and misaligned teeth
Diabetes (types 1 and 2)
Low back pain
Mental illness and mood disorders
Muscle weakness and pain
Osteomalacia (softening of bones)
Peripheral artery disease
Pelvic floor disorders
Seasonal affective disorder (SAD)
June 2, 2011
There are a significant number of men and postmenopausal women who can benefit from Testosterone Replacement Therapy. Although it is only replaced in men, women can benefit from a renewed partner.
The andropausal symptoms can be helped and even reversed by the right supplementation of testosterone into the body. The idea of testosterone therapy is to restore testosterone to youthful levels to achieve optimal health and well-being. Testosterone is a vital hormone that plays an enormous role in the sex drive of both men and women. It is known to restore healthy sexual excitement and desire, which in turn improves attitude, relationships and well-being.
The key to anti-aging is linked to simply replacing hormone levels to what they once were in our youthful days.
Male menopause is referred to as Andropause, and is very common in the average aging male. Most people are under the impression that there is no menopause for men, just women. Symptoms for the male are kept quiet and are said to just be a part of old age. Male menopause does exist and only rarely do men get “”hot flashes,”” but there is an increase in morning and nightly fatigue and the male’s erections are less often, less firm, and ejaculation takes place less often. Many men who have used Testosterone Replacement Therapy reach a maximum improvement of sexual function within 30 days. Body fat was decreased in many studies, lean muscle strength increased, and better cardiac health overall was reported.
May 5, 2011
Low testosterone levels put men at high risk for cardiovascular disease, diabetes and early death, but testosterone replacement therapy may help better the odds, according to new studies.
Some experts believe that low testosterone levels, which become more common with age, are linked to several health conditions. These include loss of bone and muscle mass, depression, decreased libido, and, most important, the metabolic syndrome — a cluster risk factors that increase the chances of developing heart disease, stroke and type 2 diabetes.
The studies, all of which were expected to be presented at The Endocrine Society’s annual meeting, in San Francisco, suggest that therapy to raise testosterone back to normal levels may have several positive effects.
One study showed that testosterone treatment significantly reduced abdominal fat, total cholesterol, LDL (“bad”) cholesterol, triglycerides and body mass index (a measure of body fat). It also helped raise HDL (“good”) cholesterol.
Researchers in a second study found that men older than 63 benefited as much as younger men.
“We conclude that if elderly men have a deficiency of testosterone, it is worthwhile to treat them with testosterone,” co-author of both studies, Farid Saad of Berlin-headquartered Bayer Schering Pharma — a drug company that makes a form of testosterone therapy — said in a prepared interview.
A third study added to previous evidence that low testosterone increases one’s chance of early death from any cause in the long run.
In the study, funded in part by drug maker Novo Nordisc, researchers looked the causes of death in almost 2,000 German men aged 20 to 79 years. The men with low testosterone at the start of study, which had an average follow up period of 7 years, had a more than 2.5 times greater risk of dying during the next 10 years compared with men with higher testosterone. These men tended to be older, fatter and had a greater prevalence of diabetes and high blood pressure than the men with higher testosterone levels, Haring said.
This difference was not explained by age, smoking, alcohol intake, level of physical activity or increased waist circumference (a risk factor for diabetes and heart disease), according to researcher author Robin Haring, a Ph.D. student from Ernst-Moritz-Arndt University of Greifswald, Institute for Community Medicine.
Low testosterone levels predicted increased risk of death from cardiovascular disease and cancer but not death of any other single cause, the study found.
April 6, 2011
The Purpose of Sermorelin Acetate Therapy
The purpose of Sermorelin Acetate Therapy is to cause the pituitary gland to increase growth hormone production in humans. The purpose of adult Sermorelin growth hormone therapy is to reverse the effects of aging and secure the extensive treatment benefits described below.
What is Sermorelin Acetate GH-RH?
Sermorelin Acetate is a “growth hormone-releasing hormone” (GHRH). This prescription drug is compounded by U.S. pharmacies pursuant to a physician’s prescription and is patient self-injected subcutaneously. It stimulates the pituitary gland to naturally produce increased amounts of human growth hormone. Sermorelin Acetate is a truncated analog of a growth hormone releasing factor (GRF 1-44) that is naturally produced by the brain to stimulate pituitary production of human growth hormone. The increased volume of human growth hormone (hGH) produced by the pituitary gland causes an increase in the production of Insulin-Like Growth Factor-1 (IGF-1) by the liver and results in the benefits of treatment provided to the adult patient.
Benefits of Sermorelin Acetate Growth Hormone Releasing Hormone Therapy
- Increases the development of lean body mass through the development of new muscle cells
- Reduces body fat through lipolysis
- Increases energy and vitality
- Increases strength
- Increases endurance
- Accelerates healing from wounds or surgery
- Strengthens the heart
- Enhances the immune system
- Increases IGF-1 production
- Improves sleep quality
- Increases calcium retention, and strengthens and increases the mineralization of bone or bone density.
- Increases protein synthesis and stimulates the growth of all internal organs except the brain.
- Plays a role in fuel homeostasis.
- Eeduces liver uptake of glucose, an effect that opposes that of insulin.
- Promotes liver glucogenesis.
- Contributes to the maintenance and function of pancreatic islets.
Sermorelin Growth Hormone (GHRH) Therapy
As a result of Sermorelin Growth Hormone (GHRH) Therapy, the increased volume of human growth hormone secreted by the stimulated pituitary gland is converted by the liver into IGF-1. The increased amount of IGF-1 in the blood stream results an increase in metabolism and growth of new cells within the body’s organs and bones. This treatment is prescribed for unlabeled use in adults to reverse the effects of aging, increase bone density, enhance the immune system, and strengthen the heart, as well as, other organs of the body. Since the increased volume of human growth hormone is produced by the body’s pituitary gland, the body’s endocrine system will not allow more growth hormone to be produced by the Sermorelin GH-RH stimulation of the pituitary than the body can safely process within the endocrine self-monitoring system.
Growth Hormone – Releasing Hormone (Sermorelin Acetate) has been specifically approved for medical use in increasing growth hormone levels in children deficient in growth hormone production. Its use to increase the growth hormone and IGF-1 levels in adults is an off-label use of this prescription drug and not the approved use. It is specifically approved only for use in children and was formerly manufactured under the prescription drug brand name of Geref.
Growth Hormone – Releasing Hormone (Sermorelin Acetate) Therapy causes the pituitary gland to increase the growth hormone and IGF-1 levels in humans. It is a prescription drug that may be prescribed for adults for unlabeled uses and the cost is about one-third the price of illegal adult synthetic, recombinant human growth hormone (HGH) injections therapy.
Growth Hormone – Releasing Hormone (Sermorelin Acetate) Therapy for Adults increases adult lean muscle mass, reduces body fat and reverses the effects of aging in adults because of the benefits flowing from its stimulation of the pituitary gland to increase production of human growth hormone and the resulting increased production of IGF-1by the liver.
Prescribing of Recombinant Human Growth Hormone (HGH) (somatropin) for Adults without Pituitary Disease is Illegal Under Federal Law, but Sermorelin Acetate GH-RH May Legally be Prescribed
As you may be aware, it is now against federal law and a felony to prescribe, possess or distribute recombinant human growth hormone (HGH) (a synthetic, genetically engineered, growth hormone (somatropin) to an adult, unless they have been diagnosed as having a pituitary disease or suffer from AIDS muscle wasting. The relevant federal statute and the assignment of jurisdiction for enforcement of this law to the U.S. Drug Enforcement Agency may be found by clicking on the link entitled “Warning to Online Buyers About Sites Offering Illegal Prescriptions” located on our website home page http://www.nationalmedicalclinic.com/ or by clicking on the following link: http://www.nationalmedicalclinic.com/comp_warning.php Many clinic owners, pharmacists and physicians have been indicted and convicted of felony distribution or possession (pharmacist dispensing or physician prescribing) of HGH for the unapproved purposes of medical rejuvenation, accelerated wound healing or anti-aging in recent years. The injection of recombinant HCG can result in the variations if growth of internal organs because the drug is not regulated by the body’s endocrine system as is Sermorelin GH-RH. However, no law prohibits the prescribing of Growth Hormone – Releasing Hormone (Sermorelin Acetate) to adults for such unlabeled purposes. Further, the possession of recombinant growth hormone illegally or invalidly prescribed by a physician results in criminal possession of the drug by the patient
Sermorelin Growth Hormone (GH-RH) Therapy offers several advantages over genetically engineered synthetic human growth hormone (HGH):
As you may be aware, it is now against federal law and a felony to prescribe, possess or distribute recombinant human growth hormone (HGH) (a synthetic, genetically engineered, growth hormone (somatropin) to an adult, unless they have been diagnosed as having a pituitary disease or suffer from AIDS muscle wasting. The relevant federal statute and the assignment of jurisdiction for enforcement of this law to the U.S. Drug Enforcement Agency may be found by clicking on the link entitled “Warning to Online Buyers About Sites Offering Illegal Prescriptions” located on our website home page http://www.nationalmedicalclinic.com/ or by clicking on the following link: http://www.nationalmedicalclinic.com/comp_warning.php Many clinic owners, pharmacists and physicians have been indicted and convicted of felony distribution or possession (pharmacist dispensing or physician prescribing) of HGH for the unapproved purposes of medical rejuvenation, accelerated wound hearing or anti-aging in recent years. The injection of recombinant HCG can result in the variations if growth of internal organs because the drug is not regulated by the body’s endocrine system as is Sermorelin GH-RH. However, no law prohibits the prescribing of Growth Hormone – Releasing Hormone (Sermorelin Acetate) to adults for such unlabeled purposes. Further, the possession of recombinant growth hormone illegally or invalidly prescribed by a physician results in criminal possession of the drug by the patient
Sermorelin Growth Hormone (GH-RH) Therapy offers several advantages over genetically engineered synthetic human growth hormone (HGH):
- Sermorelin GH-RH may legally be prescribed for unlabeled use in adults deficient in human growth hormone, while synthetic, genetically engineered (recombinant) HGH (somatropin) may not legally be prescribed for adults, except (1) to treat adult HIV muscle wasting, or (2) a growth hormone deficiency resulting from a physician diagnosed pituitary disease based upon objective diagnostic medical laboratory testing. It is a felony and federal crime for a U.S. physician, pharmacist, pharmacy, clinic, organization or person to knowingly possess or distribute synthetic, genetically engineered (recombinant) human growth hormone (somatropin or HGH) to any adult patient for the purpose of medical rejuvenation, reversing the effects of aging, accelerate recovery from surgery or injuries, strengthen the heart, or any other purpose not expressly approved by the Secretary of Health and Human Services. The applicable federal criminal statute is US Code Annotated, Title 21 Food and Drugs, Chapter 3, Subchapter III, Section 333. (e) (1).
- Sermorelin Growth Hormone (GH-RH) Therapy cost about 1/3 of the prices charged by physicians, pharmacies, clinics and others for the knowingly possessing, prescribing, distributing or dispensing of synthetic, genetically engineered human growth hormone HGH (somatropin) for unapproved and illegal medical uses ; and,
- Sermorelin Growth Hormone (GH-RH) injected into the body are safer than HGH injections because the increased human growth hormone is produced by the body’s pituitary gland; and the endocrine system will not allow the pituitary to produce more human growth hormone than the body can safely process. Therefore, the body’s organs cannot grow at different rates as they do with illegal, synthetic, recombinant, genetically engineered human growth hormone (HGH) or somatropin. Hence, a potential serious adverse side effect of excessive dosing is avoided with the use of Sermorelin Acetate.
January 3, 2011
Crohn’s disease is a chronic disorder of the gastro intestinal tract, which is characterized by inflammation, and causes difficult digestion and general disability. Crohn’s is one of the very common irritable bowel syndromes / diseases (IBS/D) which affects several hundreds of individuals. In addition to Crohn’s disease, ulcerative colitis is another IBD which is common.
There have been some research studies in the recent past, which have indicated the potential benefits of the Human Growth Hormone Replacement Therapy, to treat patients with Crohn’s disease. A dietary modification which comprises of high protein diet and an adequate intake of folvite has been suggested, in addition to the hormone replacement therapy to effectively manage the condition.
Research indicating the role of the Human Growth Hormone in the management of Crohn’s Disease
A study was conducted on thirty seven adults suffering from moderate to severe form of active Crohn’s disease, by Dr. Alfred Slonim and his colleagues at the North Shore University Hospital in Manhasset, New York. The participants were administered 5 mg of HGH with a maintenance dose of 1.5 mg for a period of four months. Also, dietary modifications were suggested to the case and the control groups.
For a period of four months, the disease activity was evaluated using Crohn’s Disease Activity Index. It was observed that in patients treated with HGH, the improvement was about 100 %. Minor side effects were observed in the case group (i.e. participants treated with HGH) which included: edema and headache, which disappeared after the first month of the treatment. The study concluded that HGH has significant benefits in the management of patients suffering from Crohn’s Disease and it also aids in making the intestinal tissue healthier. The study was published in the New England Journal of Medicine in 2000. The study also observed that the benefit of Growth hormone was similar to the use of anti inflammatory drug infliximab (which is the only approved treatment for patients with Crohn’s disease).
HGH treats Crohn’s disease effectively
Crohn’s Disease is manifested in the form of abdominal pain, diarrhea and bleeding, due to a breakdown of the intestinal wall. Unfortunately, neither the cause nor an approved treatment solution for the same is available. One of the reasons cited for the development of the condition is an exaggerated immune response which results in tissue damage.
There is little information about how HGH assists in the management of Crohn’s disease; nevertheless, a rational explanation is available. HGH improves cell mediated response to antibodies and programs the immune system to respond by creating specific antigens. This is one of the reasons why HGH has been potentially beneficial in patients suffering from HIV/AIDS or from autoimmune disorders like lupus and arthritis. Secondly, HGH promotes organ restoration and helps in the growth and proliferation of intestinal tissue, which in turn, improves the patient’s clinical condition.
The Human Growth Hormone is a potential solution for patients suffering from IBS including Crohn’s disease, especially, in conjunction with dietary and life style changes.