Injectable Branched-Chain Amino Acids (BCAA)

Injectable Branched-Chain Amino Acids (BCAA)

August 26, 2011

A new formula for injectable Branched-Chain Amino Acids (BCAA). BCAAs consist of three amino acids; Leucine, Isoleucine; and valine.  These amino acids cannot be manufactured within the human body, yet they are vital for many of our functions.  BCAAs are supplemented by athletes who require them to prevent muscle loss during exercise and to increase performance.  Just as athletes benefit from BCAAs, many patients with chronic and certain acute disease also benefit from supplementing these amino acids.

Since mammals can not biologically synthesize these branched chain amino acids, ingesting them through supplements affects the body positively not only in muscle protein synthesis, but also in fighting against some diseases such as liver failure and catabolic diseases. Red blood cells are regained, hemoglobin strength is improved and muscle inflammation is reduced[5]. Apart from benefiting the skeletal muscle, the mixture of these amino acids in proteins greatly benefit the results to certain athletes that take the right amount of the branched chain amino acids a day. Initially these amino acids already do not develop in the body, so the more these amino acids are consumed through other sources the greater chance there is of inducing a healthy diet. (Shimomura, Yoshiharu. “Branched-Chain Amino Acids in Exercise.” American society for Nutrition (2006): 1-4. Web. 5 Feb 2011)

BCAAs are commonly found OTC in capsule or powder form.  The usual oral dosage for muscle preservation and growth is 10g-50g daily.  The dosage for the injectable formula is recommended at 1ml-3ml IM following exercise or every day for chronic illness.

Side effects:  They are completely safe, no side effects.  (Mero A, Leucine Supplementation and intensive training. Sports Med. 1999:27:(6):347-358 )

Here’s the breakdown

Leucine 20mg/ml

Isoleucine 30mg/ml

Valine 80mg/ml




High levels of Estrogen Can cause depression

High levels of Estrogen Can cause depression

August 15, 2011

Estrogen and Depression

The sex difference in rates of psychiatric illness beginning at puberty and continuing throughout the reproductive years suggest that the brain’s hormonal environment is the thing which modulate the risk and severity of psychiatric morbidity. Hormones play an integral role in the development and prognosis of psychiatric disorders has been increasing attention, especially along with depression treatment. The male-female contrasts in estrogen production throughout the reproductive years are responsible for the modulating the expression of depression between the sexes. Change in mood reported during the late luteal phase of the menstrual cycle and following childbirth mainly.

There are so many causes of increase in the rate of depression at the time of menopause and the recent research for it does not found any evidence that explain that the major depression increases after menopause, at a time when estrogen levels decline. But the thing is observed that post-menopausal women are increasingly vulnerable to depression as the estrogen production reduces in them. Actually the action of estrogen on neurotransmitter and receptor functioning are having the antidepressant symptoms. The main aim of estrogen is to enhance serotonergic functions like increases synthesis and uptake, post-synaptic receptor responsivity, and leads to up-regulation of 5-HT1 and down-regulation of 5-HT2 serotonin receptors.

Estrogen also increases norepinephrine activity in the brain which are responsible for improving the mood and cognition reported in women on estrogen replacement therapy (ERT) and it also involves changes in monoamine oxidase activity. In non-depressed peri- and post-menopausal women though estrogen has been known to improve mood and sense of well being, estrogen alone but it does not improve mood in women with clinical depression. Estrogen as an adjunct to antidepressant therapy is also helpful.

Recently it is researched that the older depressed women in the age 60 years or more older on ERT who received sertraline had substantially improved well than women receiving sertraline alone. Estrogen augmentation for perimenopausal depression be reserved for a subgroup of women, those suffering from depression like postpartum depression or mood changes related to the menstrual cycle associated with changes in estrogen levels. There is a link between Estrogens and the onset, course and severity of depression suggesting estrogen supplementation may be a useful adjuvant therapy in selected depressed women.

Estrogen Source of Stress

As the survey on depression itself suggest that the stress-related depressions are seen twice in women as compared to men. Estrogens level is the main reason for this happening. Even mild levels of stress which don’t affect men, can affect female very easily as their estrogen levels were elevated as estrogen makes the brain more vulnerable to stress. High levels of estrogen increases brain’s response to stress which is responsible that women are more vulnerable to mental illnesses such as depression and post-traumatic stress disorder (PTSD) than men.

It is known that estrogen can interact with molecular processes involved in the stress response and that certain genetic variations have been demonstrated in clinically depressed women. But how these factors combine to produce the disparity in the prevalence of this disorder is unknown




Information on omega 3 and how it helps your entire body!!!!

Information on omega 3 and how it helps your entire body!!!!

August 8, 2011

Omega-3 fatty acids are considered essential fatty acids: They are necessary for human health but the body can’ t make them — you have to get them through food. Omega-3 fatty acids can be found in fish, such as salmon, tuna, and halibut, other seafood including algae and krill, some plants, and nut oils. Also known as polyunsaturated fatty acids (PUFAs), omega-3 fatty acids play a crucial role in brain function as well as normal growth and development. They have also become popular because they may reduce the risk of heart disease. The American Heart Association recommends eating fish (particularly fatty fish such as mackerel, lake trout, herring, sardines, albacore tuna, and salmon) at least 2 times a week.

Research shows that omega-3 fatty acids reduce inflammation and may help lower risk of chronic diseases such as heart disease, cancer, and arthritis. Omega-3 fatty acids are highly concentrated in the brain and appear to be important for cognitive (brain memory and performance) and behavioral function. In fact, infants who do not get enough omega-3 fatty acids from their mothers during pregnancy are at risk for developing vision and nerve problems. Symptoms of omega-3 fatty acid deficiency include fatigue, poor memory, dry skin, heart problems, mood swings or depression, and poor circulation.

It is important to have a balance of omega-3 and omega-6 (another essential fatty acid) in the diet. Omega-3 fatty acids help reduce inflammation, and most omega-6 fatty acids tend to promote inflammation. The typical American diet tends to contain 14 – 25 times more omega-6 fatty acids than omega-3 fatty acids.

The Mediterranean diet, on the other hand, has a healthier balance between omega-3 and omega-6 fatty acids. Many studies have shown that people who follow this diet are less likely to develop heart disease. The Mediterranean diet does not include much meat (which is high in omega-6 fatty acids) and emphasizes foods rich in omega-3 fatty acids, including whole grains, fresh fruits and vegetables, fish, olive oil, garlic, as well as moderate wine consumption.

Uses:

Clinical evidence is strongest for heart disease and problems that contribute to heart disease, but omega-3 fatty acids may also be used for:

High cholesterol

People who follow a Mediterranean-style diet tend to have higher HDL or “good” cholesterol levels, which help promote heart health. Inuit Eskimos, who get high amounts of omega-3 fatty acids from eating fatty fish, also tend to have increased HDL cholesterol and decreased triglycerides (fats in the blood). Several studies have shown that fish oil supplements reduce triglyceride levels. Finally, walnuts (which are rich in alpha linolenic acid or LNA, a type of omega-3 fatty acid) have been reported to lower total cholesterol and triglycerides in people with high cholesterol levels.

High blood pressure

Several clinical studies suggest that diets or fish oil supplements rich in omega-3 fatty acids lower blood pressure in people with hypertension. An analysis of 17 clinical studies using fish oil supplements found that taking 3 or more grams of fish oil daily may reduce blood pressure in people with untreated hypertension.

Heart disease

One of the best ways to help prevent heart disease is to eat a diet low in saturated fat and to eat foods that are rich in monounsaturated and polyunsaturated fats (including omega-3 fatty acids). Clinical evidence suggests that EPA and DHA (eicosapentaenoic acid and docosahexaenoic acid, the two omega-3 fatty acids found in fish oil) help reduce risk factors for heart disease, including high cholesterol and high blood pressure. Fish oil has been shown to lower levels of triglycerides (fats in the blood), and to lower risk of death, heart attack, stroke, and abnormal heart rhythms in people who have already had a heart attack. Fish oil also appears to help prevent and treat atherosclerosis (hardening of the arteries) by slowing the development of plaque and blood clots, which can clog arteries.

Large population studies suggest that getting omega-3 fatty acids in the diet, primarily from fish, helps protect against stroke caused by plaque buildup and blood clots in the arteries that lead to the brain. Eating at least 2 servings of fish per week can reduce the risk of stroke by as much as 50%. However, high doses of fish oil and omega-3 fatty acids may increase the risk of bleeding. People who eat more than 3 grams of omega-3 fatty acids per day (equivalent to 3 servings of fish per day) may have higher risk for hemorrhagic stroke, a potentially fatal type of stroke in which an artery in the brain leaks or ruptures.

Diabetes

People with diabetes often have high triglyceride and low HDL levels. Omega-3 fatty acids from fish oil can help lower triglycerides and apoproteins (markers of diabetes), and raise HDL, so eating foods or taking fish oil supplements may help people with diabetes. Another type of omega-3 fatty acid, ALA (from flaxseed, for example) may not have the same benefit as fish oil. Some people with diabetes can’ t efficiently convert LNA to a form of omega-3 fatty acids that the body can use. Also, some people with type 2 diabetes may have slight increases in fasting blood sugar when taking fish oil, so talk to your doctor to see if fish oil is right for you.

Rheumatoid arthritis

Most clinical studies examining omega-3 fatty acid supplements for arthritis have focused on rheumatoid arthritis (RA), an autoimmune disease that causes inflammation in the joints. A number of small studies have found that fish oil helps reduce symptoms of RA, including joint pain and morning stiffness. One study suggests that people with RA who take fish oil may be able to lower their dose of non-steroidal anti-inflammatory drugs (NSAIDs). However, unlike prescription medications, fish oil does not appear to slow progression of RA, only to treat the symptoms. Joint damage still occurs.

Laboratory studies suggest that diets rich in omega-3 fatty acids (and low in the inflammatory omega-6 fatty acids) may help people with osteoarthritis, although more study is needed. New Zealand green lipped mussel (Perna canaliculus), another potential source of omega-3 fatty acids, has been reported to reduce joint stiffness and pain, increase grip strength, and improve walking pace in a small group of people with osteoarthritis. For some people, symptoms got worse before they improved.

An analysis of 17 randomized, controlled clinical trials looked at the pain relieving effects of omega-3 fatty acid supplements in people with RA or joint pain caused by inflammatory bowel disease (IBS) and painful menstruation (dysmenorrhea). The results suggest that omega-3 fatty acids, along with conventional therapies such as NSAIDs, may help relieve joint pain associated with these conditions.

Systemic lupus erythematosus (SLE)

Several small studies suggest that EPA and fish oil may help reduce symptoms of lupus, an autoimmune condition characterized by fatigue and joint pain. However, two small studies found fish oil had no effect on lupus nephritis (kidney disease caused by lupus, a frequent complication of the disease).

Osteoporosis

Some studies suggest that omega-3 fatty acids may help increase levels of calcium in the body and improve bone strength, although not all results were positive. Some studies also suggest that people who don’ t get enough of some essential fatty acids (particularly EPA and gamma-linolenic acid [GLA], an omega-6 fatty acid) are more likely to have bone loss than those with normal levels of these fatty acids. In a study of women over 65 with osteoporosis, those who took EPA and GLA supplements had less bone loss over 3 years than those who took placebo. Many of these women also experienced an increase in bone density.

Depression

Studies have found mixed results as to whether taking omega-3 fatty acids can help depression symptoms. Several studies have found that people who took omega-3 fatty acids in addition to prescription antidepressants had a greater improvement in symptoms than those who took antidepressants alone. However, other studies have found no benefit.

Studies are also mixed on whether omega-3 fatty acids alone have any effect on depression. Depression is a serious illness and you should not try to treat it on your own. See a doctor for help.

Bipolar disorder

In a clinical study of 30 people with bipolar disorder, those who took fish oil in addition to standard prescription treatments for bipolar disorder for 4 months experienced fewer mood swings and relapse than those who received placebo. But another 4-month long clinical study treating people with bipolar depression and rapid cycling bipolar disorder did not find that EPA helped reduce symptoms.

Schizophrenia

Preliminary clinical evidence suggests that people with schizophrenia may have an improvement in symptoms when given omega-3 fatty acids. However, a recent well-designed study concluded that EPA supplements are no better than placebo in improving symptoms of this condition.

Attention deficit/hyperactivity disorder (ADHD)

Children with attention deficit/hyperactivity disorder (ADHD) may have low levels of certain essential fatty acids (including EPA and DHA). In a clinical study of nearly 100 boys, those with lower levels of omega-3 fatty acids had more learning and behavioral problems (such as temper tantrums and sleep disturbances) than boys with normal omega-3 fatty acid levels.

However, studies examining whether omega-3 fatty acids help improve symptoms of ADHD have found mixed results. A few studies have found that omega-3 fatty acids helped improve behavioral symptoms, but most were not well designed. One study that looked at DHA in addition to stimulant therapy (standard therapy for ADHD) found no effect. More research is needed, but eating foods that are high in omega-3 fatty acids is a reasonable approach for someone with ADHD.

Skin disorders

In one clinical study, 13 people with sun sensitivity known as photo dermatitis showed less sensitivity to UV rays after taking fish oil supplements. However, topical sunscreens are much better at protecting the skin from damaging effects of the sun than omega-3 fatty acids. In another study of 40 people with psoriasis, those who took EPA with their prescription medications did better than those treated with the medications alone. However, a larger study of people with psoriasis found no benefit from fish oil.

Inflammatory bowel disease (IBD)

Results are mixed as to whether omega-3 fatty acids can help reduce symptoms of Crohn’ s disease and ulcerative colitis, the two types of IBD. Some studies suggest that omega-3 fatty acids may help when added to medication, such as sulfasalazine (a standard medication for IBD). Others find no effect. More studies are needed. Fish oil supplements can cause side effects that are similar to symptoms of IBD (such as flatulence, belching, bloating, and diarrhea).

Asthma

Studies examining omega-3 fatty acids for asthma are mixed. In one small, well-designed clinical study of 29 children with asthma, those who took fish oil supplements rich in EPA and DHA for 10 months reduced their symptoms compared to children who took placebo. However, most studies have shown no effect.

Macular Degeneration

A questionnaire given to more than 3,000 people over the age of 49 found that those who ate more fish were less likely to have macular degeneration (a serious age-related eye condition that can progress to blindness) than those who ate less fish. Similarly, a clinical study comparing 350 people with macular degeneration to 500 without the eye disease found that those with a healthy dietary balance of omega-3 and omega-6 fatty acids and more fish in their diets were less likely to have macular degeneration.

Menstrual pain

In one study of 42 women, they had less menstrual pain when they took fish oil supplements than when they took placebo.

Coloncancer

Eating foods rich in omega-3 fatty acids seems to reduce the risk of colorectal cancer. For example, Eskimos, who tend to have a high-fat diet but eat significant amounts of fish rich in omega-3 fatty acids, have a low rate of colorectal cancer. Animal studies and laboratory studies have found that omega-3 fatty acids prevent worsening of colon cancer. Preliminary studies suggest that taking fish oil daily may help slow the progression of colon cancer in people with early stages of the disease. If you have colorectal cancer, ask your doctor before taking any supplements.

Breast cancer

Although not all experts agree, women who eat foods rich in omega-3 fatty acids over many years may be less likely to develop breast cancer. More research is needed to understand the effect that omega-3 fatty acids may have on the prevention of breast cancer.

Prostate cancer

Population based studies of groups of men suggest that a low-fat diet including omega-3 fatty acids from fish or fish oil help prevent the development of prostate cancer.

Dietary Sources:

Fish, plant, and nut oils are the primary dietary source of omega-3 fatty acids. Eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) are found in cold-water fish such as salmon, mackerel, halibut, sardines, tuna, and herring. ALA is found in flaxseeds, flaxseed oil, canola (rapeseed) oil, soybeans, soybean oil, pumpkin seeds, pumpkin seed oil, purslane, perilla seed oil, walnuts, and walnut oil. Other sources of omega-3 fatty acids include sea life such as krill and algae.

Available Forms:

Both EPA and DHA can be taken in the form of fish oil capsules. Flaxseed, flaxseed oil, fish and krill oils should be kept refrigerated. Whole flaxseeds must be ground within 24 hours of use, so the ingredients stay active. Flaxseeds are also available in ground form in a special mylar package so that the components in the flaxseeds stay active.

Be sure to buy omega-3 fatty acid supplements made by established companies who certify that their products are free of heavy metals such as mercury, lead, and cadmium.

How to Take It:

Dosing for fish oil supplements should be based on the amount of EPA and DHA, not on the total amount of fish oil. Supplements vary in the amounts and ratios of EPA and DHA. A common amount of omega-3 fatty acids in fish oil capsules is 0.18 grams (180 mg) of EPA and 0.12 grams (120 mg) of DHA. Five grams of fish oil contains approximately 0.17 – 0.56 grams (170 -560 mg) of EPA and 0.072 – 0.31 grams (72 – 310 mg) of DHA. Different types of fish contain variable amounts of omega-3 fatty acids, and different types of nuts or oil contain variable amounts of LNA. Fish oils contain approximately 9 calories per gram of oil.

Children (18 years and younger)

There is no established dose for children. Omega-3 fatty acids are used in some infant formulas. Fish oil capsules should not be used in children except under the direction of a health care provider. Children should avoid eating fish that may be high in mercury, such as shark, swordfish, king mackerel, and tilefish. (See Precautions section.)

Adults

Do not take more than 3 grams daily of omega-3 fatty acids from capsules without the supervision of a health care provider, due to an increased risk of bleeding.

  • For healthy adults with no history of heart disease: The American Heart Association recommends eating fish at least 2 times per week.
  • For adults with coronary heart disease: The American Heart Association recommends an omega-3 fatty acid supplement (as fish oils), 1 gram daily of EPA and DHA. It may take 2 – 3 weeks for benefits of fish oil supplements to be seen.
  • For adults with high cholesterol levels: The American Heart Association recommends an omega-3 fatty acid supplement (as fish oils), 2 – 4 grams daily of EPA and DHA. It may take 2 – 3 weeks for benefits of fish oil supplements to be seen.

Precautions:

Because of the potential for side effects and interactions with medications, dietary supplements should be taken only under the supervision of a knowledgeable health care provider.

Omega-3 fatty acids should be used cautiously by people who bruise easily, have a bleeding disorder, or take blood-thinning medications including warfarin (Coumadin) or clopidogrel (Plavix). High doses of omega-3 fatty acids may increase the risk of bleeding.

Fish oil can cause gas, bloating, belching, and diarrhea. Time-release preparations may reduce these side effects, however.

People with either diabetes or schizophrenia may lack the ability to convert alpha-linolenic acid (LNA) to eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), the forms more readily used in the body. People with these conditions should be sure to get enough EPA and DHA from their diets. Also, people with type 2 diabetes may experience increases in fasting blood sugar levels while taking fish oil supplements. If you have type 2 diabetes, use fish oil supplements only under the supervision of a health care provider.

Although studies suggest that eating fish (which includes the omega-3 fatty acids EPA and DHA) may reduce the risk of macular degeneration, a recent study including 2 large groups of men and women found that diets rich in LNA may increase the risk of this disease. Until more information becomes available, people with macular degeneration should get omega-3 fatty acids from sources of EPA and DHA, rather than LNA.

Fish and fish oil may protect against prostate cancer, but LNA may be associated with increased risk of prostate cancer in men. More research in this area is needed.

Some fish may contain potentially harmful contaminants, such as heavy metals (including mercury), dioxins, and polychlorinated biphenyls (PCBs). For sport-caught fish, the U.S. Environmental Protection Agency (EPA) recommends that pregnant or nursing women eat no more than a single 6-ounce meal per week, and young children less than 2 ounces per week. For farm-raised, imported, or marine fish, the U.S. Food and Drug Administration recommends that pregnant or nursing women and young children avoid eating types with higher levels of mercury (such as mackerel, shark, swordfish, or tilefish), and eat up to 12 ounces per week of other fish types.

Buy fish oil from a reputable source that tests to make sure there is no mercury or pesticide residues in its products.

Possible Interactions:

If you are currently being treated with any of the following medications, you should not use omega-3 fatty acid supplements, including eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), and alpha-linolenic acid (LNA), without first talking to your health care provider.

Blood-thinning medications — Omega-3 fatty acids may increase the effects of blood thinning medications, including aspirin, warfarin (Coumadin), and clopedigrel (Plavix). Taking aspirin and omega-3 fatty acids may be helpful in some circumstances (such as in heart disease), but they should only be taken together under the supervision of a health care provider.

Diabetes medications — Taking omega-3 fatty acid supplements may increase fasting blood sugar levels. Use with caution if taking medications to lower blood sugar, such as glipizide (Glucotrol and Glucotrol XL), glyburide (Micronase or Diabeta), glucophage (Metformin), or insulin. Your doctor may need to increase your medication dose. These drugs include:

  • Glipizide (Glucotrol and Glucotrol XL)
  • Glyburide (Micronase or Diabeta)
  • Metformin (Glucophage)
  • Insulin

Cyclosporine — Cyclosporine is a medication given to people with organ transplants. Taking omega-3 fatty acids during cyclosporine (Sandimmune) therapy may reduce toxic side effects, such as high blood pressure and kidney damage, associated with this medication.

Etretinate and topical steroids — Adding omega-3 fatty acids (specifically EPA) to the drug therapy etretinate (Tegison) and topical corticosteroids may improve symptoms of psoriasis.

Cholesterol-lowering medications — Following dietary guidelines, including increasing the amount of omega-3 fatty acids in your diet and reducing the omega-6 to omega-3 ratio, may help a group of cholesterol lowering medications known as statins to work more effectively. These medications include:

  • Atorvastatin (Liptor)
  • Lovastatin (Mevacor)
  • Simvastatin (Zocor)

Nonsteroidal anti-inflammatory drugs (NSAIDs) — In an animal study, treatment with omega-3 fatty acids reduced the risk of ulcers from nonsteroidal anti-inflammatory drugs (NSAIDs). NSAIDs include ibuprofen (Motrin or Advil) and naproxen (Aleve or Naprosyn). More research is needed to see whether omega-3 fatty acids would have the same effects in people.




Low Testosterone – what causes it?

Low Testosterone – what causes it?

August 5, 2011

What causes testosterone deficiency?

Testosterone is a hormone produced by the testicles and is responsible for the proper development of male sexual characteristics, and is important for maintaining muscle bulk, adequate levels of red blood cells, bone density, sense of well-being, and sexual and reproductive function.

Inadequate testosterone production is not a common cause of erectile dysfunction (ED). When ED does occur with decreased testosterone production, testosterone replacement therapy may improve the ED.

As a man ages, the amount of testosterone in his body gradually declines. This natural decline starts after age 30 and continues throughout life. The significance of this decline is controversial and poorly understood.

Symptoms of testosterone deficiency:

  • decreased sex drive
  • decreased sense of well-being
  • depressed mood
  • difficulties with concentration and memory
  • erectile dysfunction

What are the changes that occur in the body with testosterone deficiency?

Changes that occur with testosterone deficiency include:

  • a decrease in muscle mass, with an increase in body fat
  • variable effects on cholesterol metabolism
  • a decrease in hemoglobin and possibly mild anemia
  • fragile bones (osteoporosis)
  • a decrease in body hair

How do I find out if I have a testosterone deficiency?

The only accurate way to detect the condition is to have your doctor measure the amount of testosterone in your blood. It sometimes may take several measurements of testosterone to be sure if a patient has a deficiency, since levels of testosterone tend to fluctuate throughout the day. The highest levels of testosterone are generally in the morning. This is why doctors prefer, if possible, to obtain early morning levels of testosterone.

What options are available for testosterone replacement?

The options available for testosterone replacement are:

  • intramuscular injections, generally every two or three weeks
  • testosterone patches worn either on the body or on the scrotum (the sac that contains the testicles). These patches are used daily. The body patch application is rotated between the buttocks, arms, back or abdomen.
  • testosterone gels that are applied daily to the shoulders, upper arms, or abdomen.

For a free consultation on what would work best for you, contact us at:

info@coreinstitutes.com or call us at 866-641-CORE (2673)




Testosterone Therapy – Cypionate Description

Testosterone Therapy – Cypionate Description

May 10, 2011

Testosterone Cypionate Description

Testosterone Cypionate Injection, for intramuscular injection, contains Testosterone Cypionate which is the oil-soluble 17 (beta)- cyclopentylpropionate ester of the androgenic hormone testosterone.

Testosterone Cypionate is a white or creamy white crystalline powder, odorless or nearly so and stable in air. It is insoluble in water, freely soluble in alcohol, chloroform, dioxane, ether, and soluble in vegetable oils.

The chemical name for Testosterone Cypionate is androst-4-en-3-one,17-(3-cyclopentyl-1- oxopropoxy)-, (17β)-. Its molecular formula is C27H40O3, and the molecular weight 412.61.

The structural formula is represented below:

Testosterone Cypionate Injection is available as 200 mg/mL Testosterone Cypionate.

Each mL of the 200 mg/mL solution contains:
Testosterone Cypionate 200 mg
Benzyl benzoate 0.2 mL
Cottonseed oil 560 mg
Benzyl alcohol (as preservative) 9.45 mg

Testosterone Cypionate – Clinical Pharmacology

Endogenous androgens are responsible for normal growth and development of the male sex organs and for maintenance of secondary sex characteristics. These effects include growth and maturation of the prostate, seminal vesicles, penis, and scrotum; development of male hair distribution, such as beard, pubic, chest, and axillary hair; laryngeal enlargement, vocal cord thickening, and alterations in body musculature and fat distribution. Drugs in this class also cause retention of nitrogen, sodium, potassium, and phosphorous, and decreased urinary excretion of calcium. Androgens have been reported to increase protein anabolism and decrease protein catabolism. Nitrogen balance is improved only when there is sufficient intake of calories and protein.

Androgens are responsible for the growth spurt of adolescence and for eventual termination of linear growth, brought about by fusion of the epiphyseal growth centers. In children, exogenous androgens accelerate linear growth rates, but may cause disproportionate advancement in bone maturation. Use over long periods may result in fusion of the epiphyseal growth centers and termination of the growth process. Androgens have been reported to stimulate production of red blood cells by enhancing production of erythropoietic stimulation factor.

During exogenous administration of androgens, endogenous testosterone release is inhibited through feedback inhibition of pituitary luteinizing hormone (LH). At large doses of exogenous androgens, spermatogenesis may also be suppressed through feedback inhibition of pituitary follicle stimulating hormone (FSH).

There is a lack of substantial evidence that androgens are effective in fractures, surgery, convalescence, and functional uterine bleeding.

Pharmacokinetics

Testosterone esters are less polar than free testosterone. Testosterone esters in oil injected intramuscularly are absorbed slowly from the lipid phase; thus, Testosterone Cypionate can be given at intervals of two to four weeks.

Testosterone in plasma is 98 percent bound to a specific testosterone-estradiol binding globulin, and about 2 percent is free. Generally, the amount of this sex-hormone binding globulin in the plasma will determine the distribution of testosterone between free and bound forms, and the free testosterone concentration will determine its half-life.

About 90 percent of a dose of testosterone is excreted in the urine as glucuronic and sulfuric acid conjugates of testosterone and its metabolites; about 6 percent of a dose is excreted in the feces, mostly in the unconjugated form. Inactivation of testosterone occurs primarily in the liver. Testosterone is metabolized to various 17-keto steroids through two different pathways. The half-life of Testosterone Cypionate when injected intramuscularly is approximately eight days.

In many tissues the activity of testosterone appears to depend on reduction to dihydrotestosterone, which binds to cytosol receptor proteins. The steroid-receptor complex is transported to the nucleus where it initiates transcription events and cellular changes related to androgen action.

Indications and Usage for Testosterone Cypionate

Testosterone Cypionate Injection is indicated for replacement therapy in the male in conditions associated with symptoms of deficiency or absence of endogenous testosterone.

  1. Primary hypogonadism (congenital or acquired)-testicular failure due to cryptorchidism, bilateral torsion, orchitis, vanishing testis syndrome; or orchidectomy.
  2. Hypogonadotropic hypogonadism (congenital or acquired)-idiopathic gonadotropin or LHRH deficiency, or pituitary-hypothalamic injury from tumors, trauma, or radiation.

Contraindications

  1. Known hypersensitivity to the drug
  2. Males with carcinoma of the breast
  3. Males with known or suspected carcinoma of the prostate gland
  4. Women who are or who may become pregnant
  5. Patients with serious cardiac, hepatic or renal disease

Warnings

Hypercalcemia may occur in immobilized patients. If this occurs, the drug should be discontinued.

Prolonged use of high doses of androgens (principally the 17-β alkyl-androgens) has been associated with development of hepatic adenomas, hepatocellular carcinoma, and peliosis hepatis –all potentially life-threatening complications.

Geriatric patients treated with androgens may be at an increased risk of developing prostatic hypertrophy and prostatic carcinoma although conclusive evidence to support this concept is lacking.

Edema, with or without congestive heart failure, may be a serious complication in patients with preexisting cardiac, renal or hepatic disease. Gynecomastia may develop and occasionally persist in patients being treated for hypogonadism.

This product contains benzyl alcohol. Benzyl alcohol has been reported to be associated with a fatal “Gasping Syndrome” in premature infants. Androgen therapy should be used cautiously in healthy males with delayed puberty. The effect on bone maturation should be monitored by assessing bone age of the wrist and hand every 6 months. In children, androgen treatment may accelerate bone maturation without producing compensatory gain in linear growth. This adverse effect may result in compromised adult stature. The younger the child the greater the risk of compromising final mature height. This drug has not been shown to be safe and effective for the enhancement of athletic performance. Because of the potential risk of serious adverse health effects, this drug should not be used for such purpose.

Precautions

General

Patients with benign prostatic hypertrophy may develop acute urethral obstruction. Priapism or excessive sexual stimulation may develop. Oligospermia may occur after prolonged administration or excessive dosage. If any of these effects appear, the androgen should be stopped and if restarted, a lower dosage should be utilized.

Testosterone Cypionate should not be used interchangeably with testosterone propionate because of differences in duration of action.

Testosterone Cypionate is not for intravenous use.

Information for Patients

Patients should be instructed to report any of the following: nausea, vomiting, changes in skin color, ankle swelling, too frequent or persistent erections of the penis.

Laboratory Tests

Hemoglobin and hematocrit levels (to detect polycythemia) should be checked periodically in patients receiving long-term androgen administration.

Serum cholesterol may increase during androgen therapy.

Drug Interactions

Androgens may increase sensitivity to oral anticoagulants. Dosage of the anticoagulant may require reduction in order to maintain satisfactory therapeutic hypoprothrombinemia.

Concurrent administration of oxyphenbutazone and androgens may result in elevated serum levels of oxyphenbutazone.

In diabetic patients, the metabolic effects of androgens may decrease blood glucose and, therefore, insulin requirements.

Drug/Laboratory Test Interferences

Androgens may decrease levels of thyroxine-binding globulin, resulting in decreased total T4 serum levels and increased resin uptake of T3 and T4. Free thyroid hormone levels remain unchanged, however, and there is no clinical evidence of thyroid dysfunction.

Testosterone Cypionate Description

Testosterone Cypionate Injection, for intramuscular injection, contains Testosterone Cypionate which is the oil-soluble 17 (beta)- cyclopentylpropionate ester of the androgenic hormone testosterone.

Testosterone Cypionate is a white or creamy white crystalline powder, odorless or nearly so and stable in air. It is insoluble in water, freely soluble in alcohol, chloroform, dioxane, ether, and soluble in vegetable oils.

The chemical name for Testosterone Cypionate is androst-4-en-3-one,17-(3-cyclopentyl-1- oxopropoxy)-, (17β)-. Its molecular formula is C27H40O3, and the molecular weight 412.61.

The structural formula is represented below:

Testosterone Cypionate Injection is available as 200 mg/mL Testosterone Cypionate.

Each mL of the 200 mg/mL solution contains:
Testosterone Cypionate 200 mg
Benzyl benzoate 0.2 mL
Cottonseed oil 560 mg
Benzyl alcohol (as preservative) 9.45 mg

Testosterone Cypionate – Clinical Pharmacology

Endogenous androgens are responsible for normal growth and development of the male sex organs and for maintenance of secondary sex characteristics. These effects include growth and maturation of the prostate, seminal vesicles, penis, and scrotum; development of male hair distribution, such as beard, pubic, chest, and axillary hair; laryngeal enlargement, vocal cord thickening, and alterations in body musculature and fat distribution. Drugs in this class also cause retention of nitrogen, sodium, potassium, and phosphorous, and decreased urinary excretion of calcium. Androgens have been reported to increase protein anabolism and decrease protein catabolism. Nitrogen balance is improved only when there is sufficient intake of calories and protein.

Androgens are responsible for the growth spurt of adolescence and for eventual termination of linear growth, brought about by fusion of the epiphyseal growth centers. In children, exogenous androgens accelerate linear growth rates, but may cause disproportionate advancement in bone maturation. Use over long periods may result in fusion of the epiphyseal growth centers and termination of the growth process. Androgens have been reported to stimulate production of red blood cells by enhancing production of erythropoietic stimulation factor.

During exogenous administration of androgens, endogenous testosterone release is inhibited through feedback inhibition of pituitary luteinizing hormone (LH). At large doses of exogenous androgens, spermatogenesis may also be suppressed through feedback inhibition of pituitary follicle stimulating hormone (FSH).

There is a lack of substantial evidence that androgens are effective in fractures, surgery, convalescence, and functional uterine bleeding.

Pharmacokinetics

Testosterone esters are less polar than free testosterone. Testosterone esters in oil injected intramuscularly are absorbed slowly from the lipid phase; thus, Testosterone Cypionate can be given at intervals of two to four weeks.

Testosterone in plasma is 98 percent bound to a specific testosterone-estradiol binding globulin, and about 2 percent is free. Generally, the amount of this sex-hormone binding globulin in the plasma will determine the distribution of testosterone between free and bound forms, and the free testosterone concentration will determine its half-life.

About 90 percent of a dose of testosterone is excreted in the urine as glucuronic and sulfuric acid conjugates of testosterone and its metabolites; about 6 percent of a dose is excreted in the feces, mostly in the unconjugated form. Inactivation of testosterone occurs primarily in the liver. Testosterone is metabolized to various 17-keto steroids through two different pathways. The half-life of Testosterone Cypionate when injected intramuscularly is approximately eight days.

In many tissues the activity of testosterone appears to depend on reduction to dihydrotestosterone, which binds to cytosol receptor proteins. The steroid-receptor complex is transported to the nucleus where it initiates transcription events and cellular changes related to androgen action.

Indications and Usage for Testosterone Cypionate

Testosterone Cypionate Injection is indicated for replacement therapy in the male in conditions associated with symptoms of deficiency or absence of endogenous testosterone.

  1. Primary hypogonadism (congenital or acquired)-testicular failure due to cryptorchidism, bilateral torsion, orchitis, vanishing testis syndrome; or orchidectomy.
  2. Hypogonadotropic hypogonadism (congenital or acquired)-idiopathic gonadotropin or LHRH deficiency, or pituitary-hypothalamic injury from tumors, trauma, or radiation.

Contraindications

  1. Known hypersensitivity to the drug
  2. Males with carcinoma of the breast
  3. Males with known or suspected carcinoma of the prostate gland
  4. Women who are or who may become pregnant

10. Patients with serious cardiac, hepatic or renal disease

Warnings

Hypercalcemia may occur in immobilized patients. If this occurs, the drug should be discontinued.

Prolonged use of high doses of androgens (principally the 17-β alkyl-androgens) has been associated with development of hepatic adenomas, hepatocellular carcinoma, and peliosis hepatis –all potentially life-threatening complications.

Geriatric patients treated with androgens may be at an increased risk of developing prostatic hypertrophy and prostatic carcinoma although conclusive evidence to support this concept is lacking.

Edema, with or without congestive heart failure, may be a serious complication in patients with preexisting cardiac, renal or hepatic disease. Gynecomastia may develop and occasionally persist in patients being treated for hypogonadism.

This product contains benzyl alcohol. Benzyl alcohol has been reported to be associated with a fatal “Gasping Syndrome” in premature infants. Androgen therapy should be used cautiously in healthy males with delayed puberty. The effect on bone maturation should be monitored by assessing bone age of the wrist and hand every 6 months. In children, androgen treatment may accelerate bone maturation without producing compensatory gain in linear growth. This adverse effect may result in compromised adult stature. The younger the child the greater the risk of compromising final mature height. This drug has not been shown to be safe and effective for the enhancement of athletic performance. Because of the potential risk of serious adverse health effects, this drug should not be used for such purpose.

Precautions

General

Patients with benign prostatic hypertrophy may develop acute urethral obstruction. Priapism or excessive sexual stimulation may develop. Oligospermia may occur after prolonged administration or excessive dosage. If any of these effects appear, the androgen should be stopped and if restarted, a lower dosage should be utilized.

Testosterone Cypionate should not be used interchangeably with testosterone propionate because of differences in duration of action.

Testosterone Cypionate is not for intravenous use.

Information for Patients

Patients should be instructed to report any of the following: nausea, vomiting, changes in skin color, ankle swelling, too frequent or persistent erections of the penis.

Laboratory Tests

Hemoglobin and hematocrit levels (to detect polycythemia) should be checked periodically in patients receiving long-term androgen administration.

Serum cholesterol may increase during androgen therapy.

Drug Interactions

Androgens may increase sensitivity to oral anticoagulants. Dosage of the anticoagulant may require reduction in order to maintain satisfactory therapeutic hypoprothrombinemia.

Concurrent administration of oxyphenbutazone and androgens may result in elevated serum levels of oxyphenbutazone.

In diabetic patients, the metabolic effects of androgens may decrease blood glucose and, therefore, insulin requirements.

Drug/Laboratory Test Interferences

Androgens may decrease levels of thyroxine-binding globulin, resulting in decreased total T4 serum levels and increased resin uptake of T3 and T4. Free thyroid hormone levels remain unchanged, however, and there is no clinical evidence of thyroid dysfunction.




The Purpose of Sermorelin Acetate Therapy

The Purpose of Sermorelin Acetate Therapy

April 6, 2011

The Purpose of Sermorelin Acetate Therapy

The purpose of Sermorelin Acetate Therapy is to cause the pituitary gland to increase growth hormone production in humans. The purpose of adult Sermorelin growth hormone therapy is to reverse the effects of aging and secure the extensive treatment benefits described below.

What is Sermorelin Acetate GH-RH?

Sermorelin Acetate is a “growth hormone-releasing hormone” (GHRH). This prescription drug is compounded by U.S. pharmacies pursuant to a physician’s prescription and is patient self-injected subcutaneously. It stimulates the pituitary gland to naturally produce increased amounts of human growth hormone. Sermorelin Acetate is a truncated analog of a growth hormone releasing factor (GRF 1-44) that is naturally produced by the brain to stimulate pituitary production of human growth hormone. The increased volume of human growth hormone (hGH) produced by the pituitary gland causes an increase in the production of Insulin-Like Growth Factor-1 (IGF-1) by the liver and results in the benefits of treatment provided to the adult patient.

Benefits of Sermorelin Acetate Growth Hormone Releasing Hormone Therapy

  • Increases the development of lean body mass through the development of new muscle cells
  • Reduces body fat through lipolysis
  • Increases energy and vitality
  • Increases strength
  • Increases endurance
  • Accelerates healing from wounds or surgery
  • Strengthens the heart
  • Enhances the immune system
  • Increases IGF-1 production
  • Improves sleep quality
  • Increases calcium retention, and strengthens and increases the mineralization of bone or bone density.
  • Increases protein synthesis and stimulates the growth of all internal organs except the brain.
  • Plays a role in fuel homeostasis.
  • Eeduces liver uptake of glucose, an effect that opposes that of insulin.
  • Promotes liver glucogenesis.
  • Contributes to the maintenance and function of pancreatic islets.

Sermorelin Growth Hormone (GHRH) Therapy

As a result of Sermorelin Growth Hormone (GHRH) Therapy, the increased volume of human growth hormone secreted by the stimulated pituitary gland is converted by the liver into IGF-1. The increased amount of IGF-1 in the blood stream results an increase in metabolism and growth of new cells within the body’s organs and bones. This treatment is prescribed for unlabeled use in adults to reverse the effects of aging, increase bone density, enhance the immune system, and strengthen the heart, as well as, other organs of the body. Since the increased volume of human growth hormone is produced by the body’s pituitary gland, the body’s endocrine system will not allow more growth hormone to be produced by the Sermorelin GH-RH stimulation of the pituitary than the body can safely process within the endocrine self-monitoring system.

Growth Hormone – Releasing Hormone (Sermorelin Acetate) has been specifically approved for medical use in increasing growth hormone levels in children deficient in growth hormone production. Its use to increase the growth hormone and IGF-1 levels in adults is an off-label use of this prescription drug and not the approved use. It is specifically approved only for use in children and was formerly manufactured under the prescription drug brand name of Geref.

Growth Hormone – Releasing Hormone (Sermorelin Acetate) Therapy causes the pituitary gland to increase the growth hormone and IGF-1 levels in humans. It is a prescription drug that may be prescribed for adults for unlabeled uses and the cost is about one-third the price of illegal adult synthetic, recombinant human growth hormone (HGH) injections therapy.

Growth Hormone – Releasing Hormone (Sermorelin Acetate) Therapy for Adults increases adult lean muscle mass, reduces body fat and reverses the effects of aging in adults because of the benefits flowing from its stimulation of the pituitary gland to increase production of human growth hormone and the resulting increased production of IGF-1by the liver.

Prescribing of Recombinant Human Growth Hormone (HGH) (somatropin) for Adults without Pituitary Disease is Illegal Under Federal Law, but Sermorelin Acetate GH-RH May Legally be Prescribed

As you may be aware, it is now against federal law and a felony to prescribe, possess or distribute recombinant human growth hormone (HGH) (a synthetic, genetically engineered, growth hormone (somatropin) to an adult, unless they have been diagnosed as having a pituitary disease or suffer from AIDS muscle wasting. The relevant federal statute and the assignment of jurisdiction for enforcement of this law to the U.S. Drug Enforcement Agency may be found by clicking on the link entitled “Warning to Online Buyers About Sites Offering Illegal Prescriptions” located on our website home page http://www.nationalmedicalclinic.com/ or by clicking on the following link: http://www.nationalmedicalclinic.com/comp_warning.php Many clinic owners, pharmacists and physicians have been indicted and convicted of felony distribution or possession (pharmacist dispensing or physician prescribing) of HGH for the unapproved purposes of medical rejuvenation, accelerated wound healing or anti-aging in recent years. The injection of recombinant HCG can result in the variations if growth of internal organs because the drug is not regulated by the body’s endocrine system as is Sermorelin GH-RH. However, no law prohibits the prescribing of Growth Hormone – Releasing Hormone (Sermorelin Acetate) to adults for such unlabeled purposes. Further, the possession of recombinant growth hormone illegally or invalidly prescribed by a physician results in criminal possession of the drug by the patient

Sermorelin Growth Hormone (GH-RH) Therapy offers several advantages over genetically engineered synthetic human growth hormone (HGH):

As you may be aware, it is now against federal law and a felony to prescribe, possess or distribute recombinant human growth hormone (HGH) (a synthetic, genetically engineered, growth hormone (somatropin) to an adult, unless they have been diagnosed as having a pituitary disease or suffer from AIDS muscle wasting. The relevant federal statute and the assignment of jurisdiction for enforcement of this law to the U.S. Drug Enforcement Agency may be found by clicking on the link entitled “Warning to Online Buyers About Sites Offering Illegal Prescriptions” located on our website home page http://www.nationalmedicalclinic.com/ or by clicking on the following link: http://www.nationalmedicalclinic.com/comp_warning.php Many clinic owners, pharmacists and physicians have been indicted and convicted of felony distribution or possession (pharmacist dispensing or physician prescribing) of HGH for the unapproved purposes of medical rejuvenation, accelerated wound hearing or anti-aging in recent years. The injection of recombinant HCG can result in the variations if growth of internal organs because the drug is not regulated by the body’s endocrine system as is Sermorelin GH-RH. However, no law prohibits the prescribing of Growth Hormone – Releasing Hormone (Sermorelin Acetate) to adults for such unlabeled purposes. Further, the possession of recombinant growth hormone illegally or invalidly prescribed by a physician results in criminal possession of the drug by the patient

Sermorelin Growth Hormone (GH-RH) Therapy offers several advantages over genetically engineered synthetic human growth hormone (HGH):

  1. Sermorelin GH-RH may legally be prescribed for unlabeled use in adults deficient in human growth hormone, while synthetic, genetically engineered (recombinant) HGH (somatropin) may not legally be prescribed for adults, except (1) to treat adult HIV muscle wasting, or (2) a growth hormone deficiency resulting from a physician diagnosed pituitary disease based upon objective diagnostic medical laboratory testing. It is a felony and federal crime for a U.S. physician, pharmacist, pharmacy, clinic, organization or person to knowingly possess or distribute synthetic, genetically engineered (recombinant) human growth hormone (somatropin or HGH) to any adult patient for the purpose of medical rejuvenation, reversing the effects of aging, accelerate recovery from surgery or injuries, strengthen the heart, or any other purpose not expressly approved by the Secretary of Health and Human Services. The applicable federal criminal statute is US Code Annotated, Title 21 Food and Drugs, Chapter 3, Subchapter III, Section 333. (e) (1).
  2. Sermorelin Growth Hormone (GH-RH) Therapy cost about 1/3 of the prices charged by physicians, pharmacies, clinics and others for the knowingly possessing, prescribing, distributing or dispensing of synthetic, genetically engineered human growth hormone HGH (somatropin) for unapproved and illegal medical uses ; and,
  3. Sermorelin Growth Hormone (GH-RH) injected into the body are safer than HGH injections because the increased human growth hormone is produced by the body’s pituitary gland; and the endocrine system will not allow the pituitary to produce more human growth hormone than the body can safely process. Therefore, the body’s organs cannot grow at different rates as they do with illegal, synthetic, recombinant, genetically engineered human growth hormone (HGH) or somatropin. Hence, a potential serious adverse side effect of excessive dosing is avoided with the use of Sermorelin Acetate.



TESTOSTERONE AND HCG THERAPY – FUNCTIONS AND BENEFITS

TESTOSTERONE AND HCG THERAPY – FUNCTIONS AND BENEFITS

TESTOSTERONE AND HCG THERAPY – FUNCTIONS AND BENEFITS

Function of Testosterone

Testosterone is the most important sex hormone or androgen produced in men. The function of testosterone is primarily the producing the normal adult male characteristics. During puberty, testosterone stimulates the physical changes that constitute the attributes of the adult male.

Throughout adult life, testosterone helps maintain sex drive, the production of sperm cells, male hair patterns, muscle mass and bone mass. Testosterone is produced in men by the testes and in the outer layer of the adrenal glands.

The hypothalamus controls hormone production in the pituitary gland by means of gonadotropin-releasing hormone (GnRH). This hormone tells the pituitary gland to make follicle-stimulating hormone (FSH) and Luteinizing hormone (LH). LH orders the testes to produce testosterone. If the testes begin producing too much testosterone, the brain sends signals to the pituitary to make less LH. This, in turn, slows the production of testosterone. If the testes begin producing too little testosterone, the brain sends signals to the pituitary gland telling it to make more LH, which causes the testes to make more testosterone.

Symptoms of Low Testosterone

The failure of the testes to produce a sufficient level of testosterone in the adult male results in a low testosterone level. Physical signs of low testosterone in men may include:

  1. Declining sex drive,
  2. Erectile dysfunction (ED)
  3. Low sperm count
  4. Decrease in lean muscle mass
  5. Insomnia or sleep disorder
  6. Depression
  7. Chronic fatigue.

Conditions Causing Male Testosterone Deficiency

Testosterone deficiency can be caused by different conditions: 1) effects of aging; 2) testes based conditions; 3) genetics; and 4) conditions caused by the pituitary and hypothalamus.

  • The effects of aging on testosterone production
  • Testes disorder
  • Pituitary/Hypothalamus disorder
  • Genetically-based condition

Function of Testosterone Therapy

The function of testosterone hormone replacement therapy is to increase the level of testosterone in the adult male diagnosed with testosterone deficiency (low testosterone) or hypogonadism. Testosterone replacement should in theory approximate the natural, endogenous production of the hormone. The clinical reasons for treatment of testosterone deficiency in men include:

  • Increased male sex drive
  • Improve male sexual performance
  • Enhance mood in men
  • Reduce depression in men
  • Increased energy and vitality
  • Increase bone density
  • Increased strength and endurance
  • Reduce body fat
  • Increase body hair growth
  • Reduce risk of heart disease
  • Develop lean muscle mass with exercise

Function of HCG Therapy is to Stimulate the Testes to Prevent Loss of Natural Testosterone Production and Avoid Testicular Atrophy while the Male Patient is Undergoing Testosterone Hormone Replacement Therapy

The hormone HCG is prescribed for men in this therapy to increase natural testosterone production during the course of therapy as a result of the stimulation of the testes by the HCG. No testosterone medication is administered in this treatment. The treatment objective is to cause the male testes to naturally produce a higher volume of testosterone by HCG stimulation of his testes with the result that the patient experiences a continuing higher blood level of testosterone while on treatment. Another treatment objective is to avoid the use of any anabolic steroid and its adverse side effects upon the patient.

HCG Therapy normally increases natural testosterone production by the male testes while HCG is administered to the patient during the treatment period However, HCG Therapy can also result in a continuation of increased testosterone production and a resulting higher level of testosterone in the bloodstream after treatment is completed when the cause of the patient’s low natural LH secretion by the pituitary is not due to the patient’s natural genetics, aging process, injury to or loss of one or both testes; a medical disorder or disease affecting the testes, or castration.

HCG Therapy can result in a continuing higher level of natural testosterone production by the testes after HCG Therapy is completed when the underlying cause of the low LH secretion and resulting low testosterone production (1) is due to the prior use of one or more anabolic steroids by the patient or (2) due to the administration of testosterone in a prior hormone replacement therapy without the required concurrent HCG Therapy to prevent the patient’s endocrine system (hypothalamus pituitary-testes axis) from shutting down the natural production of testosterone by the testes and causing testicular atrophy.

Types of Testosterone Therapy for Men

A good male testosterone replacement therapy produces and maintains physiologic serum concentrations of testosterone and its active metabolites without significant adverse side effects.

The leading types of testosterone therapy for men include:

  • Testosterone Injection with HCG
  • Testosterone Transdermal Cream with HCG
  • Testosterone Transdermal Gel with HCG

Benefits of HCG Therapy for the Male Patient Undergoing Testosterone Hormone Replacement Therapy

  • Increases natural testosterone production by the testes
  • Prevents loss of natural testosterone production by the testes while the male patient is undergoing testosterone hormone replacement therapy
  • Prevents atrophy of testes while male patient is being treated with testosterone replacement therapy
  • Increases physical energy and elimination of chronic fatigue
  • Improves sex drive
  • Improves sexual performance
  • Improves mood
  • Reduces depression
  • Increases lean muscle mass
  • Increases strength and endurance as a result of exercise
  • Reduces body fat due to increased exercise
  • Increases sperm count and therefore male fertility
  • HCG Therapy can also result in a higher level of natural testosterone production after HCG Therapy is completed when the cause of a man’s current low testosterone production is the prior use of anabolic steroids that shut down or reduced the pituitary gland’s production of LH and decreased testosterone production.

Human Chorionic Gonadotropin (HCG)

HCG is compounded by a compounding pharmacy or manufactured by pharmaceutical company in 10,000 IU (International Units) for reconstitution with sterile water for injections in 10 cc vials.

HCG is a natural protein hormone secreted by the human placenta and purified from the urine of pregnant women. HCG hormone is not a natural male hormone but mimics the natural hormone LH (Luteinizing Hormone) almost identically. As a result of HCG stimulating the testes in the same manner as LH, HCG therapy increases testosterone production by the testes or male gonads as a result of HCG’s stimulating effect on the leydig cells of the testes.

The Decline in Gonadal Stimulating Pituitary Hormone LH (Leutenizing hormone)

The natural decline in male testosterone production that occurs with aging is attributed to a decline in the gonadal stimulating pituitary hormone LH (Luteinizing hormone). As a result of the hypothalamus secreting less gonadoropin-releasing hormone (GhRH), which stimulates the pituitary gland to produce LH, the pituitary gland produces declining amounts of LH. This decrease in the pituitary secretion of LH reduces the stimulation of the gonads or male testes and results in declining testosterone and sperm production due to the decreased function of the gonads. The decreased stimulation of the testes by the pituitary’s diminished secretion of LH can also cause testicular atrophy. HCG stimulates the testis in the same manner as naturally produced. HCG Therapy is administered medically to increase male fertility by stimulating the testes to produce more sperm cells and thereby increase sperm count or Spermatogenesis.

The decreased stimulation of the testes by the pituitary’s diminished secretion of LH can also cause testicular atrophy. HCG stimulates the testis in the same manner as naturally produced. HCG Therapy is administered medically to increase male fertility by stimulating the testes to produce more sperm cells and thereby increase sperm count or Spermatogenesis.

How HCG Therapy Increases Plasma Testosterone Level in Men with Low Testosterone Production

HCG therapy uses the body’s own biochemical stimulating mechanisms to increase plasma testosterone level during HCG therapy. It is used to stimulate the testes of men who are hypogonadal or lack sufficient testosterone. The male endocrine system is responsible for causing the testes to produce testosterone. The HPTA (hypothalamic-pituitary-testicular axis) regulates the level of testosterone in the bloodstream. and . The hypothalamus produces gonadotropin-releasing hormone (GnRH), which stimulates the pituitary gland to release Leutenizing hormone (LH).

LH released by the pituitary gland then travels from the pituitary via the blood stream to the testes where it triggers the production and release of testosterone. Without the continuing release of LH by the pituitary gland, the testes would shut down their production of testosterone, causing testicular atrophy and stopping natural testosterone produced by the testes.

As men age the volume of hypothalamus produced gonadotropin-releasing hormone (GnRH) declines and causes the pituitary gland to release less Luteinizing hormone (LH). The reduction if the volume of LH released by the Pituitary gland decreases the available LH in the blood stream to stimulate the testes to produce testosterone.

In males, HCG mimics LH and increases testosterone production in the testes. As such, HCG is administered to patients to increase endogenous (natural) testosterone production. The HCG medication administered combines with the patient’s own naturally available LH released into the blood stream by the Pituitary gland and thereby increases the stimulation of the testes to produce more testosterone than that produced by the Pituitary released LH alone. The additional HCG added to the blood stream combined with the Pituitary gland’s naturally produced LH triggers a greater volume of testosterone production by the testes, since HCG mimics LH and adds to the total stimulation of the testes.

HCG Clinical Pharmacology

The action of HCG is virtually identical to that of pituitary LH, although HCG appears to have a small degree of FSH activity as well. It stimulates production of gonadal steroid hormones by stimulating the interstitial cells (Leydig cells) of the testis to produce androgens.

Thus HCG sends the same message and results in increased testosterone production by the testis due to HCG’s effect on the leydig cells of the testis. HCG therapy uses the body’s own biochemical stimulating mechanisms to increase plasma testosterone level.

Following intramuscular injection, an increase in serum HCG concentrations may be observed within 2 hours; peak HCG concentrations occur within about 6 hours and persist for about 36 hours. Serum HCG concentrations begin to decline at 48 hours and approach baseline (undetectable) levels after about 72 hours.

HCG is not a steroid and is administered to assists the body in the continuing production of its own natural testosterone as a result of LH signals stimulating production of testosterone by the testis.

This LH stimulates the production of testosterone by the testes in males. Thus HCG sends the same message as LH to the testes and results in increased testosterone production by the testes due to HCG’s effect on the leydig cells of the testes. In males, hCG mimics LH and helps restore and maintain testosterone production in the testes. If HCG is used for too long and in too high a dose, the resulting rise in natural testosterone will eventually inhibit its own production via negative feedback on the hypothalamus and pituitary.

HCG therapy uses the body’s own biochemical stimulating mechanisms to increase plasma testosterone level during HCG therapy. It is used to stimulate the testes of men who are hypogonadal or lack sufficient testosterone




Symptoms of Low Testosterone

Symptoms of Low Testosterone

January 17, 2011

Testosterone is a hormone made by the body. Most of the testosterone in a man’s body is produced in the testicles. It helps:

  • Maintain reproductive tissues
  • Stimulate sperm production
  • Stimulate and maintain sexual function
  • Increase muscle mass and strength
  • Maintain bone strength

Just like your cholesterol or blood pressure, there is a numerical range of testosterone levels (also known as T levels) that are considered normal. The brain and the testicles work together to keep testosterone in this range. When levels of testosterone are below normal, the brain signals the testicles to make more. When testosterone levels reach a normal level, the brain signals the testicles to make less.

Testosterone can fall below normal levels. This can happen when a signaling problem between the brain and the testes causes a drop in the amount of testosterone that is being produced. Also, if the brain feels that there is too much testosterone in the body, it can signal the testes to cut production. Another reason Low T can occur is that your body simply can’t produce enough testosterone.

It’s natural for men to produce less testosterone as they age. What’s not a natural part of aging is a medical condition known as hypogonadism — that can be caused by Low T. Symptoms include reduced sexual function, depressed mood, and decreased energy.

The signs and symptoms of Low T may be difficult to tell from the changes that occur with normal aging. Symptoms are frequently subtle, and are similar to those caused by other medical conditions.

Your doctor can tell if you have hypogonadism by giving you a medical exam to assess your signs and symptoms, then performing blood tests. Your doctor can also decide if treatment options such as testosterone replacement therapy (TRT) could help bring the T levels back to normal.

When you look at each of the signs and symptoms individually, you may not think they point to Low T. That’s because they may be difficult to tell from the changes that occur with normal aging, and may, in fact, be caused by other medical conditions. Check out the signs and symptoms of Low T below to see if any of them apply to you:

  • Sexual dysfunction (unable to maintain erections)
  • Reduced sex drive (reduced sexual activity)
  • Decreased energy
  • Loss of body hair, reduced shaving
  • Depressed mood
  • Increase in body fat
  • Decrease in bone strength
  • Reduced muscle mass

If you think that many of these signs and symptoms apply to you, don’t ignore them. They could be a sign of Low T or other health conditions. Only your doctor can tell if you have hypogonadism by giving you a medical exam to assess your signs and symptoms, then by performing certain blood tests. So when you speak to your doctor, ask if you should be tested.

When a man’s testosterone falls below a level of around 300 ng/dL, it’s generally considered to be low. But there are treatment options that can help bring low testosterone levels back to normal and keep them there. Your doctor will tell you about the risks and benefits of treatment and can help you decide if it is right for you.




HGH Helps Manage Diabetes

HGH Helps Manage Diabetes

January 3, 2011

There is adequate experimental and clinical evidence that suggests that the use of the Human Growth Hormone can improve diabetes. In a study conducted at John Hopkins Institute, it was observed that HGH regulated glucose levels in the blood, while, concurrently reducing intra-abdominal fat. As per Dr. Hertoghe, of Brussels, HGH enhances the action of insulin and enhances the absorption of glucose by the nerve cells, cardiac cells and muscular cells. This prevents the absorption of glucose by fat cells which has a beneficial action on insulin sensitivity and controlling diabetes. Furthermore, lower levels of blood sugar reduce other harmful complications of diabetes including, diabetic retinopathy, cardiac illness and peripheral nerve disease.

Research to substantiate the role of HGH in improving diabetes

In a study conducted by Johannson and his colleagues, at the Salgrenska University Hospital, it was found that HGH helps improve insulin sensitivity. The study design was a randomized double blind study involving 30 men between the age groups of 48 years to 66 years. These individuals were given low doses of HGH for a period of nine months, and great benefits of the same were observed. Glucose metabolism improved considerably, along with an average reduction of 18.1 % of abdominal fat, which has been considered to be a major cause of insulin resistance. The study concluded that HGH replacement therapy helps improve insulin sensitivity and assists in regulation of blood sugar levels.

In another double blind study conducted in 1997, it was observed that IGF-1 (an intermediate factor secreted by the liver on stimulation by HGH) can reduce the need for insulin by up to 45 %, in patients suffering with insulin dependent diabetes mellitus. The study involved eight adults, between the age group of 24 to 49 years, and forty three children between the ages of 8 to 17 years.

IGF-1 was also found to lower the levels of cholesterol and triglycerides in the blood after a mere four days of treatment. The study was a short clinical trail lasting for four weeks. No serious side effects of HGH replacement therapy were observed in any of the participants.

As per Dr. Fahy at the Naval Medical Research Institute, experiments have shown that HGH is beneficial in controlling diabetes and can be considered as a possible cure for adult onset diabetes.

How does HGH help improve diabetes?

Most of the potential benefits of HGH replacement therapy, for the management of diabetes, arises from the production of IGF-1 (a factor which is released by the liver on stimulation by HGH). IGF-1 is insulin like growth factor which has action similar to insulin and enhances the absorption of glucose from the blood by cells in the body.
Under normal conditions, glucose is absorbed by the adipose cells / fat cells, after requisite amounts of glucose are absorbed by other body cells (i.e. skeletal muscles, cardiac muscles and nerve tissue). However, with IGF-1 in the blood, the absorption of glucose by body cells in increased in comparison to adipose tissue cells. This has a dual advantage of reducing the fat deposition in the body and concurrently reducing the levels of blood sugar. HGH also has a potent action on improving protein metabolism and enhancing protein synthesis. This in turn regulates glucose metabolism in the body and increases sensitivity of receptors to insulin.

There is overwhelming evidence of the immense benefits of HGH replacement therapy in the management of insulin dependent diabetes. Though, it is recommended that the treatment should be taken in conjunction to dietary measures, the benefits of the treatment are many, including averting the detrimental side effects of diabetes like – diabetic retinopathy, kidney damage and a likelihood of developing cardio vascular disease.




Human Growth Hormone for Anti-Aging

Human Growth Hormone for Anti-Aging

December 23, 2010

As the master hormone, controlling most of the functions in our body, the Human Growth Hormone (HGH) has been claimed to have several anti aging properties.

As a person ages, the hormonal levels in the body tend to fall. Clinical evidence and research studies suggest that HGH levels fall after the third decade of life at the rate of 14% per decade, so that, by the age of eighty years, a person produces only a fraction of the hormone produced during childhood. This information is based on a study conducted by Dr. Klatz of the American Academy of Anti Aging Medicine, which indicated that the prime cause of aging was a fall in production of Growth Hormone. As per the study, by the age of 80 years, the production of HGH is barely enough to allow rebuilding of muscles and tissues.

Today in the United States alone, there are several thousands of individuals who use HGH products in different forms, for anti aging. As per an estimate, there are about 20,000 to 30,000 American adults taking HGH injections, annually, for anti aging, while almost a million adults use other products like HGH sprays or HGH supplements.